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Lercanidipine Hydrochloride

Lercanidipine Hydrochloride

Product ID L1869
Cas No. 132866-11-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $68.30 In stock
50 mg $131.30 In stock
250 mg $183.80 In stock
1 g $262.50 In stock
Bulk Quote

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  • Description
  • Product Info
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  • Downloads
  • References
  • Description
  • Product Info
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Description

Lercanidipine is a dihydropyridine calcium channel blocker. It significantly countered wall thickening and luminal narrowing on small sized arteries. This compound and other similar dihydropyridine-type Ca2+ antagonists exert protective effect on retinal that include reduced thickness of retina and of inner plexiform, outer nuclear and layer of inner and outer segments plus outer limiting layer, and loss of ganglionic neurons. Lercanidipine consistently decreased MMP-9 activity and reduced oxidative stress in hypertensive patients. Lercanidipine treatment of spontaneously hypertensive rats (SHR) during 6 weeks was able to revert the deleterious effects of hypertension on cortical bone density and on the number of TRAP+ cells in the tibia of SHR.

Product Info

Cas No.

132866-11-6

Purity

≥98%

Formula

C36H41N3O6・HCl

Formula Wt.

648.20

Chemical Name

5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride

IUPAC Name

1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)

Synonym

Cardiovasc, Corifeo

Solubility

Soluble in DMSO (100 mM), ethanol (10 mM), water (partly), chloroform, and methanol.

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

L1869 MSDS PDF

Info Sheet

L1869 Info Sheet PDF

References

Sabbatini M1, Leonardi A, Testa R, et al. Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 2002 Jan;39(1):39-48. PMID: 11743226.

Sabbatini M1, Tomassoni D, Di Tullio MA, Amenta F. Neuroprotective effect of treatment with calcium antagonists on hypertensive retina. Clin Exp Hypertens. 2002 Oct-Nov;24(7-8):727-40. PMID: 12450247.

Martinez ML1, Lopes LF, Coelho EB, et al. Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension. J Cardiovasc Pharmacol. 2006 Jan;47(1):117-22. PMID: 16424795.

Bastos MF1, Vasconcelos de Araújo I, et al. Effects of lercanidipine on bone density and bone repair in spontaneously hypertensive rats. Implant Dent. 2013 Feb;22(1):49-54. doi: 10.1097/ID.0b013e3182777650. PMID: 23287976.

Custom Order

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