• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Lorlatinib

Lorlatinib

Product ID L582694
Cas No. 1454846-35-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $92.60 In stock
25 mg $374.90 In stock
100 mg $1,124.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lorlatinib is a 3rd generation macrocyclic ALK inhibitor that shows significant improvement of inhibition against ROS1 kinase over 2nd generation inhibitors. Several cancers, when treated by ALK inhibitors, eventually develop point mutations, making the treatment ineffective. In a glioblastoma tumor model genetically engineered to reproduce ROS1 mutation, lorlatinib was yet able to demonstrate anticancer activity. Lorlatinib has also been shown to be effective as a single agent treatment on a mouse model of neuroblastoma. In addition, PET studies have found that lorlatinib successfully penetrates the blood-brain barrier resulting in high brain permeability of this inhibitor.

Product Info

Cas No.

1454846-35-5

Purity

≥98%

Formula

C21H19FN6O2

Formula Wt.

406.21

Chemical Name

7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile

IUPAC Name

(16R)-19-Amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetraazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10,12,14,18,20-octaene-3-carbonitrile

Synonym

PF-6463922, PF-06463922

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L582694 MSDS PDF

Info Sheet

L582694 Info Sheet PDF

References

Zou HY, Li Q, Engstrom LD, et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Proc Natl Acad Sci USA. 2015 Mar 17;112(11):3493-3498. PMID: 25733882.

Basit S, Ashraf Z, Lee K, et al. First macrocyclic 3rd-generation ALK inhibitor for treatment of ALK/ROS1 cancer: clinical and designing strategy update of lorlatinib. Eur J Med Chem. 2017 Jul 7;134:348-356. PMID: 28431340.

Guan J, Tucker ER, Wan H, et al. The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN. Dis Model Mech. 2016 Sep 1;9(9):941-952. PMID: 27483357.

Collier TL, Maresca KP, Normandin MD, et al. Brain penetration of the ROS1/ALK inhibitor lorlatinib confirmed by PET. Mol Imaging. 2017 Jan-Dec;16:1536012117736669. PMID: 29067878.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C0027

    Cafestol Linoleate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • G3458

    Ginsenoside Rg1

    Triterpene saponin found in species of Panax.

    ≥98%
  • P7057

    Protodioscin

    Saponin found in Dioscorea; Na+/K+ ATPase and C...

    ≥98%
  • R8178

    Rutaecarpine

    Indoloquinazoline alkaloid found in Evodia; COX...

    ≥98%
  • I538583

    Inosine

    Adenosine analog

    ≥98%
  • D1746

    Deltarasin Hydrochloride Trihydrate

    PDEδ inhibitor.

    ≥99%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • F4581

    5-Fluorocytosine

    Synthetic antifungal.

    ≥98%
  • V0147

    Valproic Acid Sodium

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • C224760

    CFT-7455

    Degrader of IKZF1/3

    ≥98%
  • V720004

    VS-4718

    Focal adhesion kinase (FAK) inhibitor.

    ≥99%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • M3309

    Miconazole

    Imidazole; 14-α demethylase inhibitor, potenti...

    ≥98%
  • A7669

    A-type Natriuretic Peptide (1-28), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • A4847

    Amylin, human

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • B5044

    BML-277

    Arylbenzimidazole; CHK2 inhibitor.

    ≥98%
  • D1776

    Desmopressin

    Synthetic vasopressin derivative; V2R agonist.<...

    ≥95%
  • C084099

    CCCP

    Efflux pump inhibitor

    ≥99%
  • Z0944

    ZCL-278

    Cdc42 inhibitor.

    ≥98%
  • T3034

    Thienylethyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only