Description
LXH254 is a type II RAF inhibitor.
Product Unit Size | Cost | Quantity | Stock |
---|
LXH254 is a type II RAF inhibitor.
Cas No. | 1800398-38-2 |
---|---|
Purity | ≥99% |
Formula | C25H25F3N4O4 |
Formula Wt. | 502.49 |
IUPAC Name | N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide |
Synonym | Naporafenib |
Appearance | White powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204
Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462
p110γ PI3K inhibitor, potential TRPC1/5/6 nega...
Synthetic progestogen; PR agonist.
Flavonoid originally found in Silybum (milk thi...
σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7...
Endogenous peptide hormone fragment, involved i...
Peptide, confers resistance against macrolide a...
Smoothened agonist.
Camptothecin analog; topoisomerase I inhibitor,...
Active isomer of epinephrine, endogenous hormon...
Corticosteroid; glucocorticoid agonist.
BK/SK, Kv1, Kv3, TASK-2 K+ channel blocker, vol...
Polymer precursor
Neuromodulator, biomarker
Fibrate; PPARα agonist, enoyl-CoA reductase in...
Benzimidazole; microtubule polymerization inhib...
Orexin 2 receptor antagonist
FGFR inhibitor.
MDM2 inhibitor.
5-HT1A agonist, 5-HT2A antagonist.
PDK1 inhibitor.