LKT Labs

Biochemicals for Life Science Research

LXH254

LXH254

Product ID L930280
Cas No. 1800398-38-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $61.00 In stock
5 mg $248.00 In stock
10 mg $441.00 In stock
25 mg $717.00 In stock
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Description

LXH254 is a type II RAF inhibitor.

Product Info

Cas No.

1800398-38-2
Purity

≥99%
Formula

C25H25F3N4O4
Formula Wt.

502.49
IUPAC Name

N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide
Synonym

Naporafenib
Appearance

White powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

Info Sheet

L930280 Info Sheet PDF

References

Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204

Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462

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