• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
LXH254

LXH254

Product ID L930280
Cas No. 1800398-38-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $60.70 In stock
5 mg $248.10 In stock
10 mg $441.00 In stock
25 mg $716.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LXH254 is a type II RAF inhibitor.

Product Info

Cas No.

1800398-38-2

Purity

≥99%

Formula

C25H25F3N4O4

Formula Wt.

502.49

IUPAC Name

N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide

Synonym

Naporafenib

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

L930280 Info Sheet PDF

References

Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204

Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E6432

    (−)-Epinephrine

    Active isomer of epinephrine, endogenous hormon...

    ≥98%
  • A6982

    Artesunate

    Sesquiterpene lactone derived from Artemesia.

    ≥98%
  • Z0944

    ZCL-278

    Cdc42 inhibitor.

    ≥98%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity

  • S800000

    SU-9516

    CDK2 inhibitor.

    ≥98%
  • B8275

    n-Butyric Acid

    Fatty acid found in dairy products; HDAC inhibi...

    ≥98%
  • N3584

    Nivalenol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥98%
  • V1871

    Veratridine

    Binds to neurotoxin receptor site 2 on voltage-...

    ≥98%
  • C000171

    C-171

    STING inhibitor

    ≥98%
  • D0260

    DAPT

    γ-Secretase inhibitor.

    ≥98%
  • D1628

    5,6-Dehydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • S8012

    [Sar9]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • A0961

    Adrenocorticotropic Hormone (1-39), rat

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • A7462

    Aspartame

    Dipeptide ester, commercial sweetener.

    ≥98%
  • C5647

    Colistin Sulfate

    Polymixin, antimicrobial peptide, induces forma...

    Biological Potency: ≥19366 IU/mg
  • M1769

    Meropenem Trihydrate

    β-lactam carbapenem; penicillin binding protei...

    ≥98%
  • O9322

    Oxfendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • U6857

    Urodilatin CCC

    ANP fragment, natriuretic peptide; Na+/K+ ATPas...

    ≥98%
  • A0916

    Acepromazine Maleate

    Phenothiazine derivative; D1/2 and 5-HT1A/2A an...

    ≥99%
  • R2810

    Recombinant Multi-epitope Chimeric HIV Antigen 1

    Recombinant HIV-1 multi-epitope chimeric antige...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only