Description
LXH254 is a type II RAF inhibitor.
LXH254
Product ID L930280
Cas No. 1800398-38-2
Purity ≥99%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 1800398-38-2 |
|---|---|
| Purity | ≥99% |
| Formula | C25H25F3N4O4 |
| Formula Wt. | 502.49 |
| IUPAC Name | N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide |
| Synonym | Naporafenib |
| Appearance | White powder |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204
Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462