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LXH254

LXH254

Product ID L930280
Cas No. 1800398-38-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $61.00 In stock
5 mg $248.00 In stock
10 mg $441.00 In stock
25 mg $717.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LXH254 is a type II RAF inhibitor.

Product Info

Cas No.

1800398-38-2

Purity

≥99%

Formula

C25H25F3N4O4

Formula Wt.

502.49

IUPAC Name

N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide

Synonym

Naporafenib

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

L930280 Info Sheet PDF

References

Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204

Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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