• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
MGCD-0103

MGCD-0103

Product ID M2409
Cas No. 726169-73-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $76.10 In stock
25 mg $253.20 In stock
50 mg $379.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MGCD-0103 (Mocetinostat) is a benzamide histone deacetylase (HDAC) inhibitor that exhibits anticancer chemotherapeutic, anti-fibrotic, antihypertensive, and cardiomodulatory activities. MGCD-0103 is currently in clinical trials as a potential treatment for several leukemias and lymphomas. In sham hearts, MGCD-0103 improves left ventricular and end diastolic pressure and decreases total collagen levels; in CD90+ cells, it decreases levels of collagen III, matrix metalloproteinase 2, and α-SMA. In other models, MGCD-0103 increases natriuretic peptide receptor (NPR1) promoter activity, increasing transcription of guanyl cyclase A/natriuretic peptide receptor A. MGCD-0103 also decreases pulmonary artery pressure, right ventricular hypertrophy, and vascular remodeling in animal models of myocardial infarction and heart failure. Additionally, this compound induces apoptosis, activates PI3K/Akt/mTOR signaling, and decreases autophagy in chronic lymphocytic leukemia (CLL) cells.

Product Info

Cas No.

726169-73-9

Purity

≥98%

Formula

C23H20N6O

Formula Wt.

396.44

IUPAC Name

N-(2-Aminophenyl)-4-({[4-(3-pyridinyl)-2-pyrimidinyl]amino}methyl)benzamide

Synonym

Mocetinostat

Solubility

DMSO 13 mg/mL (32.79 mM) Water Insoluble Ethanol Insoluble

Appearance

Off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M2409 MSDS PDF

Info Sheet

M2409 Info Sheet PDF

References

Nural-Guvener HF, Zakharova L, Nimlos J, et al. HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation. Fibrogenesis Tissue Repair. 2014 Jul 2;7:10. PMID: 25024745.

Kumar P, Tripathi S, Pandey KN. Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-a gene: interactive roles of modified histones, histone acetyltransferase, p300, AND Sp1. J Biol Chem. 2014 Mar 7;289(10):6991-7002. PMID: 24451378.

El-Khoury V, Pierson S, Szwarcbart E, et al. Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. Leukemia. 2014 Aug;28(8):1636-46. PMID: 24418989.

Cavasin MA, Demos-Davies K, Horn TR, et al. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 2;110(5):739-48. PMID: 22282194.

Younes A, Oki Y, Bociek RG, et al. Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial. Lancet Oncol. 2011 Dec;12(13):1222-8. PMID: 22033282.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D3201

    Diallyl Sulfide

    Organosulfur found in garlic.

    ≥98%
  • M1678

    2-Methoxyestradiol

    Estradiol metabolite; microtubule depolymerizat...

    ≥98%
  • G1869

    Geranylgeraniol

    Diterpene alcohol, geranylgeranyl pyrophosphate...

    ≥85%
  • D3372

    Disodium Cycloheptylaminomethylene Diphosphate

    Bisphosphonate; squalene synthase inhibitor.

    ≥98%
  • L961000

    LY-3295668

    Aurora kinase A inhibitor

    ≥99%
  • T2930

    Thiabendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • C5771

    Corticosterone

    Endogenous steroid hormone involved in immune r...

    ≥98%
  • E6398

    EPZ-5676

    DOT1L HMT inhibitor.

    ≥98%
  • A965121

    AZD-5438

    Inhibitor of CDK.

    ≥98%
  • R2714

    Recombinant HCV-NS5 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • A971334

    Azilsartan

    Sartan

    ≥98%
  • N3310

    Nicotinamide

    Amide form of vitamin B3 required for productio...

    ≥98%
  • O9396

    Oxytetracycline

    Tetracycline; protein translation inhibitor.

    ≥96%
  • N5986

    Novobiocin Sodium

    Aminocoumarin; bacterial DNA gyrase inhibitor.<...

    ≥98%
  • V024761

    Vatalanib

    Inhibitor of VEGFR1/2/3.

    ≥98%
  • M0172

    Mastoparan

    Antimicrobial peptide found in Vespula lewisii,...

    ≥95%
  • P1869

    Perindopril Erbumine

    ACE inhibitor.

    ≥95%
  • D3353

    Diminazene Aceturate

    Diamidine; ACE2 activator, DNA polymerase inhib...

    ≥98%
  • A2244

    Aflatoxicol

    Mycotoxin, metabolite of aflatoxin B1 produced ...

    ≥98%
  • D3214

    2′,3′-Dideoxyinosine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only