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Mifepristone

Mifepristone

Product ID M3321
Cas No. 84371-65-3
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $41.00 In stock
500 mg $173.70 In stock
1 g $306.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mifepristone is a synthetic steroid that exhibits abortifacient, contraceptive, neuroprotective, cognition enhancing, and antidepressant activities. Mifepristone inhibits the glucocorticoid receptor and progesterone receptor; it prevents ovulation and induces endometrial decidual degeneration. In vitro, mifepristone protects hippocampal cultures against oxidative stress and cell death induced by amyloid-β (Aβ), glutamate, and H2O2, suggesting potential benefit in the treatment of Alzheimer’s disease. Mifepristone also improves cognitive function, working memory, and spatial memory and improve symptoms of depression in clinical settings.

Product Info

Cas No.

84371-65-3

Purity

≥98%

Formula

C29H35NO2

Formula Wt.

429.59

Chemical Name

(11β,17β)-11-[4-(Dimethylamino)phenyl]-17- hydroxy-17-(1-propynyl)estra-4,9-dien-3-one

IUPAC Name

(8S,11R,13S,14S, 17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1, 2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Synonym

RU-486, Mifegyne, Mifeprex

Melting Point

150°C

Solubility

Soluble in methanol, chloroform, or acetone.

Appearance

Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3321 MSDS PDF

Info Sheet

M3321 Info Sheet PDF

References

Fiala C, Gemzel-Danielsson K. Review of medical abortion using mifepristone in combination with a prostaglandin analogue. Contraception. 2006 Jul;74(1):66-86. PMID: 16781264.

Young AH, Gallagher P, Watson S, et al. Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology. 2004 Aug;29(8):1538-45. PMID: 15127079.

Behl C, Trapp T, Skutella T, et al. Protection against oxidative stress-induced neuronal cell death--a novel role for RU486. Eur J Neurosci. 1997 May;9(5):912-20. PMID: 9182944.

Custom Order

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