• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
MK-0524

MK-0524

Product ID M4100
Cas No. 571170-77-9
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $68.30 In stock
5 mg $131.30 In stock
25 mg $393.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MK-0524 is a specific prostaglandin D2 receptor (DP1) inhibitor that functions as an inverse agonist. MK-0524 decreases niacin-induced flushing during niacin treatment of dyslipidemia and is most often studied in combination with niacin. The ability of MK-0524 to inhibit DP1 prevents PGD2-induced hyaluron synthesis, yielding beneficial results in preventing pathological changes associated with thyroid eye disease. This compound also has antithrombotic activity, displaying weak inhibitory action against the thromboxane A2 receptor, inhibiting platelet activation at high concentrations.

Product Info

Cas No.

571170-77-9

Purity

≥99%

Formula

C21H19ClFNO4S

Formula Wt.

435.90

IUPAC Name

2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid

Synonym

Laropiprant

Melting Point

178.6°C

Solubility

Soluble in ethanol, DMSO, DMF, DMSO : PBS (pH 7.2) (1:1), and water (0.5 mg/ml at 25° C)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M4100 MSDS PDF

Info Sheet

M4100 Info Sheet PDF

References

Labrecque P, Roy SJ, Fréchette L, et al. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One. 2013 Jun 10;8(6):e65767. PMID: 23762421.

Philipose S, Konya V, Lazarevic M, et al. Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation. PLoS One. 2012;7(8):e40222. PMID: 22870195.

Guo N, Baglole CJ, O'Loughlin CW, et al. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. J Biol Chem. 2010 May 21;285(21):15794-804. PMID: 20308056.

Luo WL, Crumley T, Ebel D, et al. Single therapeutic and supratherapeutic doses of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, do not prolong the QTcF interval in healthy volunteers. J Clin Pharmacol. 2010 Nov;50(11):1273-9. PMID: 20107202.

Paolini JF, Bays HE, Ballantyne CM, et al. Extended-release niacin/laropiprant: reducing niacin-induced flushing to better realize the benefit of niacin in improving cardiovascular risk factors. Cardiol Clin. 2008 Nov;26(4):547-60. PMID: 19031552.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • C0247

    Calcineurin Autoinhibitory Peptide

    Peptide; calcineurin inhibitor.

    ≥95%
  • R0154

    Ranolazine Dihydrochloride

    Nav1.7 and Nav1.8 N1+ channel blocker.

    ≥98%
  • A5031

    4-Aminophenylphosphate Disodium

    Alkaline phosphatase substrate used to quantify...

    ≥98%
  • P333400

    PIK-75

    p110α inhibitor.

    ≥99%
  • T0251

    Tamsulosin Hydrochloride

    α1-adrenergic antagonist.

    ≥98%
  • A0777

    ABT-263

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥99%
  • C9778

    Cytarabine

    Pyrimidine nucleoside (cytidine) analog; DNA ch...

    ≥98%
  • C2943

    Chlorogenic Acid (from Eucommia)

    Polyphenol derivative of caffeic acid found in ...

    ≥98%
  • S0225

    SAG Dihydrochloride

    Smoothened agonist.

    ≥98%
  • S1605

    Secretin, human

    Endogenous peptide hormone, involved in water h...

    ≥95%
  • A5035

    5-Aminosalicylic Acid

    Salicylic acid derivative; PPARγ agonist, pote...

    ≥98%
  • A5373

    Anisomycin

    Peptidyl transferase inhibitor, protein transla...

    ≥98%
  • A5334

    Anisodamine

    Tropane alkaloid found in Solanaceae plants; α...

    ≥97%
  • G1308

    GDC-0032

    PI3K inhibitor.

    ≥98%
  • P9767

    Pyriproxyfen

    Juvenile insect hormone mimic.

    ≥95%
  • D1792

    Dextromethorphan Hydrobromide Hydrate

    σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7...

    ≥98%
  • B8072

    3-tert-Butyl-5-Methoxycatechol

    BHA derivative, cellular differentiation induce...

    ≥95%
  • A0963

    Adrenocorticotropic Hormone (1-10), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • K1677

    Ketoprofen

    NSAID; COX-1/2 and lactate dehydrogenase inhibi...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only