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Moclobemide

Moclobemide

Product ID M5610
Cas No. 71320-77-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $118.40 In stock
25 mg $218.70 In stock
100 mg $638.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Moclobemide is a reversible inhibitor of MAO-A that exhibits antidepressant, anti-inflammatory, antinociceptive, and neuromodulatory activities. Moclobemide decreases immobility time in animals undergoing the forced swim test and suppresses LPS-induced increases in IL-1β and TNF-α expression in glial cells. Additionally, moclobemide increases latency time in animal models of thermal pain through an α2-adrenergic receptor-mediated pathway. Moclobemide also induces hippocampal neurogenesis, upregulating progenitor cell proliferation and expression of BDNF in vitro.

Product Info

Cas No.

71320-77-9

Purity

≥98%

Formula

C13H17ClN2O2

Formula Wt.

268.74

IUPAC Name

4-chloro-N-(2-morpholin-4-ylethyl)benzamide

Solubility

Soluble in isopropanol, methanol, DMSO (>20 mg/ml), ethanol (100 mM), and water (partly miscible)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M5610 MSDS PDF

Info Sheet

M5610 Info Sheet PDF

References

Bielecka AM, Paul-Samojedny M, Obuchowicz E. Moclobemide exerts anti-inflammatory effect in lipopolysaccharide-activated primary mixed glial cell culture. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):409-17. PMID: 20811738.

Li YF, Zhang YZ, Liu YQ, et al. Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. Acta Pharmacol Sin. 2004 Nov;25(11):1408-12. PMID: 15525460.

Schreiber S, Getslev V, Weizman A, et al. The antinociceptive effect of moclobemide in mice is mediated by noradrenergic pathways. Neurosci Lett. 1998 Sep 11;253(3):183-6. PMID: 9792241.

Ferigolo M, Barros HM, Marquardt AR, et al. Comparison of behavioral effects of moclobemide and deprenyl during forced swimming. Pharmacol Biochem Behav. 1998 Jun;60(2):431-7. PMID: 9632226.

Custom Order

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