LKT Labs

Biochemicals for Life Science Research

Montelukast Sodium

Montelukast Sodium

Product ID M5756
Cas No. 151767-02-1
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $81.70 In stock
25 mg $142.90 In stock
100 mg $408.30 In stock
Bulk Quote

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Description

Montelukast is an antagonist at cysteinyl leukotriene 1(CysLT1) receptors; it exhibits anti-allergic, anti-asthma, anti-inflammatory, analgesic, anti-tussive, and bronchodilatory activities. Montelukast is clinically used to treat allergic rhinitis and asthma, although it also attenuates cough and decreases eosinophil infiltration. Montelukast decreases expression of p38 MAPK, NF-κB, IL-1β, IL-6, and TNF-α and inhibits activation of microglia, attenuating neuropathic pain in animal models of chronic constrictive injury (CCI).

Product Info

Cas No.

151767-02-1
Purity

≥98%
Formula

C35H35ClNO3S Na
Formula Wt.

608.17
Chemical Name

1-((((1R)-1-(3-((1E)-2-(7-chloro-2- quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1- methylethyl)phenyl)propyl)thio)methyl)-Cyclopropaneacetic acid, monosodium salt
IUPAC Name

sodium;2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3- [2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl] acetate
Synonym

Singulair
Solubility

Soluble in ethanol, DMSO.
Appearance

Off-white to pale yellow hygroscopic powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

M5756 MSDS PDF
Info Sheet

M5756 Info Sheet PDF

References

Zhou C, Shi X, Huang H, et al. Montelukast Attenuates Neuropathic Pain Through Inhibiting p38 Mitogen-Activated Protein Kinase and Nuclear Factor-Kappa B in a Rat Model of Chronic Constriction Injury. Anesth Analg. 2014 May;118(5):1090-6. PMID: 24686047.

Niimi A. Cough, asthma, and cysteinyl-leukotrienes. Pulm Pharmacol Ther. 2013 Oct;26(5):514-9. PMID: 23774534.

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