Name: N(α),N(α)-Dimethyl-L-Arginine Ammonium
SKU: A6828
Availability: InStock

Description

Nα,Nα-Dimethyl-L-arginine is also known as asymmetrical dimethyl-L-arginine (ADMA). This compound is an endogenous inhibitor of NOS and is involved in the regulation of the water/sodium balance. High levels of ADMA are associated with obesity, atherosclerosis, renal disease, and coronary artery disease. ADMA aggravates gastric mucosal lesions in vivo, increasing levels of TNF-α and suppressing gastric blood flow.

Product Info

Purity	≥98%
Formula	C₈H₁₈N₄O₂ • NH₃
Formula Wt.	219.28

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A6828 MSDS PDF
Info Sheet	A6828 Info Sheet PDF

References

Mauricio MD, Aldasoro M, Ortega J, et al. Endothelial dysfunction in morbid obesity. Curr Pharm Des. 2013;19(32):5718-29. PMID: 23448493.

Szlachcic A, Krzysiek-Maczka G, Pajdo R, et al. The impact of asymmetric dimethylarginine (ADAMA), the endogenous nitric oxide (NO) synthase inhibitor, to the pathogenesis of gastric mucosal damage. Curr Pharm Des. 2013;19(1):90-7. PMID: 22950506.

Twardowski ZJ. Sodium, hypertension, and an explanation of the "lag phenomenon" in hemodialysis patients. Hemodial Int. 2008 Oct;12(4):412-25. PMID: 19090863.

Surdacki A. L-arginine analogs--inactive markers or active agents in atherogenesis? Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):302-11. PMID: 18855643.

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N(α),N(α)-Dimethyl-L-Arginine Ammonium

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