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Nabumetone is a 1-naphthalenacetic acid derivative non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2. Nabumetone exhibits anti-inflammatory, analgesic, anticancer, and chemopreventive activities. In vivo, nabumetone inhibits intestinal carcinogenesis. In vitro, this compound induces apoptosis in colon cancer cells.
| Cas No. | 42924-53-8 |
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| Purity | ≥98% |
| Formula | C15H16O2 |
| Formula Wt. | 228.29 |
| Chemical Name | 4-(6-Methoxy-2-naphthalenyl)-2-butanone |
| IUPAC Name | 4-(6-methoxynaphthalen-2-yl)butan-2-one |
| Synonym | Arthaxan, Balmox, Consolan, Nabuser, Relafen, Relifen |
| Melting Point | 80°C |
| Solubility | Soluble in DMSO. Insoluble in water. |
| Appearance | White or almost white crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Paul S, Das N, Ghosh S. The effects of aceclofenac and nabumetone in osteoarthritis. JNMA J Nepal Med Assoc. 2009 Apr-Jun;48(174):121-5. PMID: 20387351.
Roy HK, Karoski WJ, Ratashak A, et al. Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. Br J Cancer. 2001 May 18;84(10):1412-6. PMID: 11355956.