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Nexturastat A is an inhibitor of histone deacetylase 6 (HDAC 6) that exhibits immunomodulatory and anticancer chemotherapeutic activities. In melanoma cells, nexturastat A inhibits cell proliferation, upregulates expression of MHC class I, and induces G1 phase cell cycle arrest without stimulating apoptosis. In animal models of melanoma, this compound delays tumor growth.
| Cas No. | 1403783-31-2 |
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| Purity | ≥98% |
| Formula | C19H23N3O3 |
| Formula Wt. | 341.41 |
| IUPAC Name | 4-{[Butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide |
| Solubility | DMSO 68 mg/mL Ethanol 2 mg/mL Water Insoluble |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Woan KV, Lienlaf M, Perez-Villaroel P, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Mol Oncol. 2015 Apr 24. [Epub ahead of print]. PMID: 25957812.