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Nocodazole

Nocodazole

Product ID N5409
Cas No. 31430-18-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $102.00 In stock
50 mg $357.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nocodazole is an inhibitor of microtubule polymerization that exhibits anticancer and anti-parasitic activities. Nocodazole induces depolarization of the mitochondrial membrane, caspase activation, PARP cleavage, and apoptosis in chronic lymphocytic leukemia (CLL) cells. Nocodazole also kills Alveococcus larvocysts in vivo.

Product Info

Cas No.

31430-18-9

Purity

≥98%

Formula

C14H11N3O3S

Formula Wt.

301.32

Chemical Name

[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]- carbamic acid methyl ester

IUPAC Name

methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

Synonym

Oncodazole, R 17934

Melting Point

300°C (dec)

Solubility

Soluble in DMSO. Insoluble in water.

Appearance

Off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

N5409 MSDS PDF

Info Sheet

N5409 Info Sheet PDF

References

Shkoliar NA, Kukhaleva IV, Legon'kov IuA, et al. Study of the therapeutic activity of nocodazole on experimental models of larval alveococcosis. Med Parazitol (Mosk). 2013 Apr-Jun;(2):20-7. PMID: 24003517.

Beswick RW, Ambrose HE, Wagner SD. Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leuk Res. 2006 Apr;30(4):427-36. PMID: 16162358.

Rahajeng J, Giridharan SS, Naslavsky N, Caplan S. Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem. 2010 Oct 15;285(42):31918-31922. PMID: 20801876.

Custom Order

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