Description
NVP-AUY922 is an isoxazole-based inhibitor of heat shock protein 90 (HSP90) that displays anticancer chemotherapeutic and anti-angiogenic activities. NVP-AUY922 inhibits cell growth in pancreatic and colorectal cancer cells. In adult T-cell leukemia cells, NVP-AUY922 induces G1 phase cell cycle arrest and apoptosis, suppressing cell growth. Additionally, this compound induces tumor regression and decreases microvessel density in animal models of breast cancer, ovarian cancer, prostate cancer, and melanoma.