LKT Labs

Biochemicals for Life Science Research

NVP-AUY922

NVP-AUY922

Product ID N8660
Cas No. 747412-49-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $79.00 In stock
5 mg $126.00 In stock
10 mg $210.00 In stock
Bulk Quote

Quicklinks

Description

NVP-AUY922 is an isoxazole-based inhibitor of heat shock protein 90 (HSP90) that displays anticancer chemotherapeutic and anti-angiogenic activities. NVP-AUY922 inhibits cell growth in pancreatic and colorectal cancer cells. In adult T-cell leukemia cells, NVP-AUY922 induces G1 phase cell cycle arrest and apoptosis, suppressing cell growth. Additionally, this compound induces tumor regression and decreases microvessel density in animal models of breast cancer, ovarian cancer, prostate cancer, and melanoma.

Product Info

Cas No.

747412-49-3
Purity

≥98%
Formula

C26H31N3O5
Formula Wt.

465.54
IUPAC Name

5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Synonym

VER-52296, Luminespib, AUY922
Solubility

DMSO 93 mg/mL warmed (199.76 mM) Ethanol 31 mg/mL (66.58 mM) Water Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N8660 MSDS PDF
Info Sheet

N8660 Info Sheet PDF

References

Kim SH, Kang JG, Kim CS, et al. Novel Heat Shock Protein 90 Inhibitor NVP-AUY922 Synergizes With the Histone Deacetylase Inhibitor PXD101 in Induction of Death of Anaplastic Thyroid Carcinoma Cells. J Clin Endocrinol Metab. 2015 Feb;100(2):E253-61. PMID: 25389633.

Taniguchi H, Hasegawa H, Sasaki D, et al. Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells. Cancer Sci. 2014 Dec;105(12):1601-8. PMID: 25263741.

Eccles SA, Massey A, Raynaud FI, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res. 2008 Apr 15;68(8):2850-60. PMID: 18413753.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L960004

    LY-404187

    Selective positive allosteric modulator of AMPA...

    ≥98%
  • E537331

    Enniatin Complex

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • C0154

    7-Ethyl-10-hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • S8345

    S-(−)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥99%
  • M0278

    Matrine

    Alkaloid found in Sophora.

    ≥98%
  • A4497

    Alyssin Sulfone

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • T7133

    Trimetazidine Dihydrochloride

    Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...

    ≥99%
  • R4132

    RKI-1447

    ROCK1/2 inhibitor.

    ≥98%
  • B4796

    BLZ-945

    CSF-1R Inhibitor.

    ≥95%
  • V0376

    Vatalanib Dihydrochloride

    VEGFR inhibitor.

    ≥98%
  • B4517

    Bleomycin A5 Hydrochloride

    Glycopeptide, induces DNA strand breaks.

    ≥90%
  • P3597

    Pizotyline Malate

    5-HT1A partial agonist, 5-HT2C antagonist.

    ≥98%
  • R1627

    Regorafenib Anhydrous

    Multikinase inhibitor.

    ≥99%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.

    ≥98%
  • M1779

    Methyldopa Sesquihydrate

    DOPA decarboxylase inhibitor, indirect α2-adre...

    ≥98%
  • P6801

    Pravastatin Sodium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • E6134

    Epimedin C

    Flavonoid found in Epimedium sagittatum.

    ≥98%
  • C3477

    Citalopram Hydrobromide

    SERT inhibitor.

    ≥98%