LKT Labs

Biochemicals for Life Science Research

NVP-AUY922

NVP-AUY922

Product ID N8660
Cas No. 747412-49-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $78.80 In stock
5 mg $126.00 In stock
10 mg $210.00 In stock
Bulk Quote

Quicklinks

Description

NVP-AUY922 is an isoxazole-based inhibitor of heat shock protein 90 (HSP90) that displays anticancer chemotherapeutic and anti-angiogenic activities. NVP-AUY922 inhibits cell growth in pancreatic and colorectal cancer cells. In adult T-cell leukemia cells, NVP-AUY922 induces G1 phase cell cycle arrest and apoptosis, suppressing cell growth. Additionally, this compound induces tumor regression and decreases microvessel density in animal models of breast cancer, ovarian cancer, prostate cancer, and melanoma.

Product Info

Cas No.

747412-49-3
Purity

≥98%
Formula

C26H31N3O5
Formula Wt.

465.54
IUPAC Name

5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Synonym

VER-52296, Luminespib, AUY922
Solubility

DMSO 93 mg/mL warmed (199.76 mM) Ethanol 31 mg/mL (66.58 mM) Water Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N8660 MSDS PDF
Info Sheet

N8660 Info Sheet PDF

References

Kim SH, Kang JG, Kim CS, et al. Novel Heat Shock Protein 90 Inhibitor NVP-AUY922 Synergizes With the Histone Deacetylase Inhibitor PXD101 in Induction of Death of Anaplastic Thyroid Carcinoma Cells. J Clin Endocrinol Metab. 2015 Feb;100(2):E253-61. PMID: 25389633.

Taniguchi H, Hasegawa H, Sasaki D, et al. Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells. Cancer Sci. 2014 Dec;105(12):1601-8. PMID: 25263741.

Eccles SA, Massey A, Raynaud FI, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res. 2008 Apr 15;68(8):2850-60. PMID: 18413753.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7329

    Ethoxyquin

    Quinoline, food preservative; HSP90 inhibitor.<...

    ≥90%
  • A046189

    Abexinostat

    Primarily targets HDAC1

    ≥98%
  • O938567

    4-epi-6-Oxodocetaxel

    Docetaxel impurity

    ≥95%
  • G7240

    GSK-2830371

    Wip1 inhibitor.

    ≥98%
  • R5874

    Rosmarinic Acid

    Caffeic acid ester found in Melissa, Salvia, an...

    ≥98%
  • A0958

    Aconitine

    Toxin found in Aconitum; voltage-gated Na+ chan...

    ≥95%
  • I5210

    INCB018424

    JAK1/2 inhibitor.

    ≥98%
  • N344780

    N-Nitroso Bumetanide

    Bumetanide impurity

    ≥99%
  • N7604

    Naltriben

    δ2OR antagonist.

    ≥95%
  • I7458

    1-Isothiocyanato-9-(methylsulfinyl)-nonane

    ITC, sulforaphane analog.

    ≥98%
  • S3353

    Sinomenine Hydrochloride

    Alkaloid found in Sinomenium; acid-sensing ion ...

    ≥98%
  • D0808

    DCC-2036

    Abl inhibitor.

    ≥98%
  • E6356

    Epothilone D

    Microtubule depolymerization inhibitor.

    ≥98%
  • P9671

    Pyrazinamide

    Nicotinamide analog prodrug; fatty acid synthet...

    ≥98%
  • M0272

    Mastoparan 7

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • M1626

    Megestrol Acetate

    Synthetic progestogen, orexigenic.

    ≥98%
  • F1655

    Fenoprofen Calcium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥97%
  • P2012

    PF-04217903

    Triazolopyrazine; c-MET inhibitor.

    ≥98%
  • D1770

    Dermorphin Analog

    Synthetic peptide; dermorphin analog; δOR and ...

    ≥95%
  • C8500

    CV-65

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%