• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
NVP-BHG712

NVP-BHG712

Product ID N8460
Cas No. 940310-85-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $58.50 In stock
5 mg $162.30 In stock
25 mg $486.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NVP-BHG712 is an orally active selective inhibitor of EphB4, which plays a significant role in vessel development, vascular development, and tumor angiogenesis. This compound exhibits anticancer chemotherapeutic and anti-angiogenic activity, inhibiting EphB4 autophosphorylation and VEGF-induced angiogenesis.

Product Info

Cas No.

940310-85-0

Purity

≥98%

Formula

C26H20F3N7O

Formula Wt.

503.48

Chemical Name

4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide -

IUPAC Name

4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3, 4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide

Synonym

BHG712

Solubility

DMSO 101 mg/mL (200.6 mM) Ethanol 3 mg/mL (5.95 mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N8460 MSDS PDF

Info Sheet

N8460 Info Sheet PDF

References

Wnuk M, Hlushchuk R, Janot M, et al. Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 2012 Jun;81(12):1212-25. PMID: 22398409.

Martiny-Baron G, Holzer P, Billy E, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67. PMID: 20803239.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • V344766

    Vitexin

    Found in hawthorn.

    ≥98%
  • S3568

    Siramesine

    σ2 agonist.

    ≥98%
  • A2532

    AGI-6780

    Isocitrate dehydrogenase inhibitor.

    ≥98%
  • C167200

    Cefazolin

    Cephalosporin analogue

    ≥98%
  • M8007

    Mubritinib, Free Base

    EGFR2 inhibitor.

    ≥99%
  • P5845

    Polydatin

    Stilbenoid glucoside found in Polygonum.

    ≥97%
  • M0040

    M40

    Peptide; galanin antagonist.

    ≥95%
  • C0029

    Cafestol Oleate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • SB5776

    Snake venom – Bothrops alternatus (urutu)

    Snake venom found in Bothrops alternatus urutu....

    ≥98%
  • I7357

    Isorhamnetin

    Flavonol found in Tagetes.

    ≥98%
  • A7461

    Asperosaponin VI

    Triterpene saponin found in Dipsacus asper.

    ≥98%
  • L5750

    Lomeguatrib

    MGMT inhibitor.

    ≥98%
  • C9876

    CYT-387

    JAK2 inhibitor.

    ≥98%
  • R3220

    Rifampicin

    Ansamycin; bacterial DNA-dependent RNA polymera...

    ≥98%
  • T1855

    Tentoxin

    Cyclic peptide mycotoxin produced by Alternaria...

    ≥98%, HPLC
  • G720004

    GS-4997

    ASK1 inhibitor.

    ≥99%
  • T3100

    Thyrotropin-releasing Hormone

    Endogenous tripeptide, involved in HPA signalin...

    ≥95%
  • N344784

    N-Nitroso Valsartan

    Valsartan impurity

    ≥98%
  • T7133

    Trimetazidine Dihydrochloride

    Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only