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NVP-BHG712

NVP-BHG712

Product ID N8460
Cas No. 940310-85-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $58.50 In stock
5 mg $162.30 In stock
25 mg $486.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NVP-BHG712 is an orally active selective inhibitor of EphB4, which plays a significant role in vessel development, vascular development, and tumor angiogenesis. This compound exhibits anticancer chemotherapeutic and anti-angiogenic activity, inhibiting EphB4 autophosphorylation and VEGF-induced angiogenesis.

 

Product Info

Cas No.

940310-85-0

Purity

≥98%

Formula

C26H20F3N7O

Formula Wt.

503.48

Chemical Name

4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide -

IUPAC Name

4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3, 4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide

Synonym

BHG712

Solubility

DMSO 101 mg/mL (200.6 mM) Ethanol 3 mg/mL (5.95 mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N8460 MSDS PDF

Info Sheet

N8460 Info Sheet PDF

References

Wnuk M, Hlushchuk R, Janot M, et al. Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 2012 Jun;81(12):1212-25. PMID: 22398409.

Martiny-Baron G, Holzer P, Billy E, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67. PMID: 20803239.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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