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Osthole

Osthole

Product ID O7377
Cas No. 484-12-8
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $141.80 In stock
1 g $394.50 In stock
5 g $1,577.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Osthole is an O-methylated coumarin that inhibits Ca2+ channels. It exhibits anticancer, antioxidative, anti-inflammatory, and cardioprotective activities. In glioblastoma cells, osthole inhibits IGF-1-induced epithelial-to-mesenchymal transition (EMT), decreases phosphorylation of Akt and GSK-3β, inhibiting cell migration. Osthole also exhibits anti-metastatic potential in lung cancer cells, inhibiting migration and invasion by decreasing expression of matrix metalloproteinases 2 and 9 (MMP2/9). In animal models of ischemia/reperfusion, osthole decreases levels of ROS, malondialdehyde, IL-6, TNF-α, and myeloperoxidase, increases activity of superoxide dismutase, and improves lung injury pathology. Osthole also inhibits lung inflammation induced by administration of carrageenan in vivo. In animal models of cardiac ischemia/reperfusion, this compound inhibits lipid peroxidation and decreases expression of HMGB1 and NF-κB.

Product Info

Cas No.

484-12-8

Purity

≥98%

Formula

C15H16O3

Formula Wt.

244.29

Chemical Name

2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)- (9CI)

IUPAC Name

7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one

Synonym

Osthol, Ostol, Ostole.

Melting Point

83-84°C

Solubility

Practically insoluble in water. Soluble in aq alkalies, alcohol, chloroform or acetone.

Appearance

Light Yellow Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O7377 MSDS PDF

Info Sheet

O7377 Info Sheet PDF

References

Lin YC, Lin JC, Hung CM, et al. Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells. J Agric Food Chem. 2014 May 14. [Epub ahead of print]. PMID: 24828835.

Li Z, Ji H, Song X, et al. Osthole attenuates the development of carrageenan-induced lung inflammation in rats. Int Immunopharmacol. 2014 May;20(1):33-6. PMID: 24576740.

Mo LQ, Chen Y, Song L, et al. Osthole prevents intestinal ischemia-reperfusion-induced lung injury in a rodent model. J Surg Res. 2014 Mar 15. [Epub ahead of print]. PMID: 24726060.

Wang XY, Dong WP, Bi SH, et al. Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med. 2013 Aug;32(2):365-72. PMID: 23695269.

Xu XM, Zhang Y, Qu D, et al. Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Mol Med Rep. 2012 Nov;6(5):1018-22. PMID: 22923177.

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