• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
OTSSP167 Hydrochloride

OTSSP167 Hydrochloride

Product ID O783743
Cas No. 1431698-10-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.60 In stock
5 mg $306.70 In stock
25 mg $953.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

OTSSP167 inhibits maternal embryonic leucine zipper kinase (MELK). MELK has been identified as a possible therapeutic target for breast cancer, and is highly upregulated in other cancer types. OTSSP167 suppresses mammosphere formation of breast cancer cells and tumor growth in xenograft studies. In epithelial ovarian cancer, treatment with OTSSP167 reduced cell proliferation through G2/M cell cycle arrest resulting in apoptosis, even in cisplatin-resistant and paclitaxel-resistant cancer cells.

Product Info

Cas No.

1431698-10-0

Purity

≥98%

Formula

C25H29Cl3N4O2

Formula Wt.

523.88

IUPAC Name

1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone;hydrochloride

Synonym

OTS167 Hydrochloride; OTSSP167 (hydrochloride); OTSSP167 HCL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

O783743 MSDS PDF

Info Sheet

O783743 Info Sheet PDF

References

Chung S., Suzuki H., et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. (12):1629-40 (2012). PMID: 23283305.

Kholer R., Kettelhack H., et al. MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells. Gynecol Oncol. 145(1):159-166 (2017). PMID: 28214016.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F5773

    Fosinopril Sodium

    ACE inhibitor.

    ≥98%
  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • T6930

    Triclosan Methyl Ether

    Diarylether; bacterial ENR binder, fatty acid s...

    ≥99%
  • A5219

    Anethole Trithione

    Oltipraz analog, salivary gland secretion enhan...

    ≥98%
  • L1982

    Leupeptin Hemisulfate

    Protease inhibitor.

    ≥95%
  • A1370

    Adrenomedullin (22-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • T1777

    S,S-(+)-Tetrandrine

    Benzylisoquinoline alkaloid originally found in...

    ≥98%
  • P2303

    Phallacidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥98%
  • M1977

    Metronidazole

    Nitroimidazole; DNA synthesis inhibitor.

    ≥98%
  • N5767

    Norethindrone

    Steroid hormone, contraceptive; PR agonist.

    ≥98%
  • C0154

    7-Ethyl-10-hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • A0099

    A-779

    Mas antagonist.

    ≥95%
  • A980005

    AZ-5104

    Inhibitor of EGFR.

    ≥98%
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in am...

    ≥95%
  • M1744

    Melittin

    Antimicrobial peptide found in Apis mellifera.<...

    ≥95%
  • F8270

    Furosemide

    Loop diuretic; NKCC symporter inhibitor, CFTR C...

    ≥97%
  • C3251

    Cinnarizine

    FIASMA, L-type Ca2+ channel blocker, D2 antagon...

    ≥98%
  • M0248

    Manidipine Dihydrochloride

    Dihydropyridine; L-type and T-type Ca2+ channel...

    ≥99%
  • D3429

    Dihydrocytochalasin B

    Mycotoxin derivative; actin polymerization inhi...

    ≥98%
  • A4944

    Amlexanox

    Azoxanthone derivative; S100A12 and S100A13 inh...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only