Description
Oxazolidine Cabazitaxel is an impurity in the synthesis of the anti-cancer compound cabazitaxel.
Product Unit Size | Cost | Quantity | Stock |
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Oxazolidine Cabazitaxel is an impurity in the synthesis of the anti-cancer compound cabazitaxel.
Cas No. | 1373171-12-0 |
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Purity | ≥95% |
Formula | C48H61NO14 |
Formula Wt. | 875.41 |
IUPAC Name | 5-O-[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-2-benzoyloxy-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-15-yl] 3-O-tert-butyl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate |
Synonym | (4S,5R)-2,2-Dimethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 5-[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl] 3-(1,1-dimethylethyl) ester |
Store Temp | -20°C |
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Ship Temp | Ambient |
Info Sheet |
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Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.
Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.
Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.
Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.
Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.
GABA-A positive modulator.
Vitamin D, calcitriol prodrug; VDR agonist.
Histamine H1 antagonist.
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5...
Glutathione-ITC conjugate, antioxidant.
β2-adrenergic agonist.
Protein translation inhibitor.
ATM and ATR inhibitor.
Synthetic quinone CoQ analog, promotes mitochon...
Polyether pyrrole, divalent cation ionophore.
Synthetic derivative of 6-methylsulfinyl-hexane...
Alkaloid found in Catharanthus, precursor in sy...
Anxiolytic-like agent that stimulates angiogene...
5-HT2/3/6/7, D2/3/4, histamine H1, α1-adrenerg...
D2 agonist, NMDA, 5-HT3, α7 nAChR antagonist.<...
nNOS inhibitor.
Sesquiterpene lactone derived from Artemesia.
PKA inhibitor, potential ROCK, S6K1, MSK1, PKB ...
Peptide, c-Kit ligand fragment.