LKT Labs

Biochemicals for Life Science Research

Pantoprazole

Product ID P0255
Cas No. 102625-70-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $82.70 In stock
500 mg $238.10 In stock
1 g $397.00 In stock
Bulk Quote

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Description

Pantoprazole is an H+/K+ ATPase inhibitor that exhibits antacid, anti-parasitic, and anticancer chemotherapeutic activities. Pantoprazole is clinically used to treat gastroesophageal reflux disease (GERD), although its inhibition of ROCK-2 causes a decrease in gastroesophageal sphincter muscle tone. In Trichomonas, pantoprazole inhibits uridine nucleoside ribohydrolase activity. Additionally, pantoprazole increases tumor-associated macrophage recruitment in the tumor microenvironment, inhibiting tumor growth in vivo.

Product Info

Cas No.

102625-70-7
Purity

≥98%
Formula

C16H15F2N3O4S
Formula Wt.

383.37
Chemical Name

5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)- methyl]sulfinyl]-1H-benzimidazole

IUPAC Name

6-(difluoromethoxy)-2-[(3, 4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Synonym

SKF-96022, BY-1023
Melting Point

139-140°C (dec)
Solubility

Soluble in methanol. Soluble in water (48 mg/ml).
Appearance

Off-White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P0255 MSDS PDF
Info Sheet

P0255 Info Sheet PDF

References

Welsh C, Kasirer MY, Pan J, et al. Pantoprazole decreases gastroesophageal muscle tone in newborn rats via rho-kinase inhibition. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 3. [Epub ahead of print]. PMID: 24699328.

Shea TA, Burburan PJ, Matubia VN, et al. Identification of proton-pump inhibitor drugs that inhibit Trichomonas vaginalis uridine nucleoside ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4. PMID: 24468412.

Ward RM, Kearns GL. Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Paediatr Drugs. 2013 Apr;15(2):119-31. PMID: 23512128.

Vishvakarma NK, Singh SM. Immunopotentiating effect of proton pump inhibitor pantoprazole in a lymphoma-bearing murine host: Implication in antitumor activation of tumor-associated macrophages. Immunol Lett. 2010 Nov 30;134(1):83-92. PMID: 20837061.

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