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Pefloxacin is a synthetic third generation fluoroquinolone antibiotic. Pefloxacin displays antibacterial activity; it inhibits DNA gyrase and topoisomerase IV, suppressing DNA replication and transcription. Additionally, pefloxacin inhibits synthesis of penicillin-binding proteins, preventing bacterial cell wall formation. Pefloxacin exhibits moderate UV-induced phototoxicity.
| Cas No. | 149676-40-4 |
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| Purity | ≥98% |
| Formula | C17H20FN3O3 • CH3SO3H • 2H2O |
| Formula Wt. | 465.50 |
| Chemical Name | 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1- piperazinyl)-4-oxo-3-quinolinecarboxylic acid monomethanesulfonate |
| IUPAC Name | 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid |
| Synonym | Pefloxacine mesylate, Peflacine, Peflox |
| Appearance | Almost White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
MartÃnez LJ, Sik RH, Chignell CF. Fluoroquinolone antimicrobials: singlet oxygen, superoxide and phototoxicity. Photochem Photobiol. 1998 Apr;67(4):399-403. PMID: 9559584.
Grossato A, Fontana R. Synergy and mechanism of interaction between pefloxacin and penicillin G against enterococci. New Microbiol. 1997 Jul;20(3):221-5. PMID: 9258941.
Moreau NJ, Houot S, Joly-Guillou ML, et al. Characterisation of DNA gyrase and measurement of drug accumulation in clinical isolates of Acinetobacter baumannii resistant to fluoroquinolones. J Antimicrob Chemother. 1996 Dec;38(6):1079-83. PMID: 9023657.