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Penicillin G procaine

Penicillin G procaine

Product ID P1852
Cas No. 6130-64-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $35.20 In stock
25 g $48.60 In stock
100 g $139.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Penicillin G is a hydrophobic β-lactam antibiotic that displays antibacterial efficacy against gram positive bacteria. Penicillin G is more active than penicillin V against gram negative bacteria but exhibits poor oral absorption kinetics and must be administered by parenteral injection. Penicillin G inhibits cell wall synthesis and does not display effective inhibition of β-lactamase-producing bacteria. Penicillin G may induce open channel or competitive block of neuromuscular nicotinic acetylcholine receptors (nAChRs).

Product Info

Cas No.

6130-64-9

Purity

≥98%

Formula

C29H38N4O6S • H2O

Formula Wt.

588.73

Chemical Name

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[( phenoxyacetyl)- amino]-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid with 2-(diethylamino)ethyl 4-aminobenzoate (1:1) monohydrate

IUPAC Name

2-(diethylamino)ethyl 4-aminobenzoate;(2S,5R,6R)-3, 3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid;hydrate

Synonym

Benzylpenicillin Procaine salt, Abbocillin, Duracillin, Pfizerpen-AS

Melting Point

106-110°C (dec)

Solubility

Soluble at about 28oC in: water (6.8mg/mL), methanol (>20mg/mL), ethanol (33 mg/mL), and isopropanol (6.5mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P1852 MSDS PDF

Info Sheet

P1852 Info Sheet PDF

References

Sun S, Selmer M, Andersson DI. Resistance to β-lactam antibiotics conferred by point mutations in penicillin-binding proteins PBP3, PBP4 and PBP6 in Salmonella enterica. PLoS One. 2014 May 8;9(5):e97202. PMID: 24810745.

Schlesinger F, Krampfl K, Haeseler G, et al. Competitive and open channel block of recombinant nAChR channels by different antibiotics. Neuromuscul Disord. 2004 May;14(5):307-12. PMID: 15099589.

Demain AL. Production of beta-lactam antibiotics and its regulation. Proc Natl Sci Counc Repub China B. 1991 Oct;15(4):251-65. PMID: 1815263.

Bär H, Zarnack J. Molecular-biological bases of the mechanism of action of penicillins and cephasporins. Pharmazie. 1970 Jan 1;25(1):10-22. PMID: 4987180.

Custom Order

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