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Peptide 401 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps. Peptide 401 induces mast cell degranulation, activating histamine release from peritoneal mast cells. Additionally, peptide 401 exhibits some anti-inflammatory activity, decreasing paw edema in animal models.
| Cas No. | 32908-73-9 |
|---|---|
| Purity | ≥95% |
| Formula | C110H188N40O24S4 |
| Formula Wt. | 2583.28 |
| Synonym | Mast Cell Degranulating Peptide |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Banks BE, Dempsey CE, Vernon CA, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4. PMID: 2328399.
Ennis M, Atkinson G, Pearce FL. Inhibition of histamine release induced by compound 48/80 and peptide 401 in the presence and absence of calcium. Implications for the mode of action of anti-allergic compounds. Agents Actions. 1980 Jun;10(3):222-8. PMID: 6157320.
Hanson JM, Morley J, Soria-Herrera C. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92. PMID: 4152780.