PF-3845

Name: PF-3845
SKU: P200000
Availability: InStock

Product ID P200000

Cas No. 1196109-52-0

Purity ≥98%

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Description

PF-3845 is an inhibitor of fatty acid amide hydrolase (FAAH). PF-3845 shows anti-allodynic effects in mice stimulated with LPS. It generates this effect without displaying any cannabinolic effects, making it a target for inflammatory pain management. When PF-3845 is used in tandem with the monoacyglycerol lipase (MAGL) inhibitor JZL184, it lessens withdrawal effects from opioid-dependent mice and produces anti-nociceptive effects without cannabimimetic side effects. Studies of PF-3845 treatment for traumatic brain injury in mice showed that PF-3845 lessened impairments found in control mice.

Product Info

Cas No.	1196109-52-0
Purity	≥98%
Formula	C₂₄H₂₃F₃N₄O₂
Formula Wt.	456.47
Chemical Name	N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide hydrate
IUPAC Name	N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide
Synonym	PF3845
Solubility	DMSO (>45 mg/mL)
Appearance	White to off-white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	P200000 MSDS PDF
Info Sheet	P200000 Info Sheet PDF

References

Booker L, Kinsey SG, Abdullah RA et al. The fatty acid hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. Br J Pharmacol. 2012 Apr;165(8):2485-96. PMID: 21506952.

Ramesh D, Gamage TF, Vanuytsel T et al. Dual Inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice. Neuropsychopharmacology. 2013 May;38(6):1039-49. PMID: 23303065

Tchantchou F, Tucker LB, Fu AH, et al. The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury. Neuropharmacology. 2014 Oct;85:427-39. PMID: 24937045

Ghosh S, Kinsey SG Liu QS et al. Full Fatty ACid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimemetic Side Effects in Mice. J Pharmacol Exp Ther. 2015 Aug;354(2):111-20. PMID25998048.

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PF-3845

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Description

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