Description
Phorbol 12,3-dibutyrate (PDBu) activates PKC and PKD and induces apoptosis and differentiation in leukemia cells. PBDu is carcinogenic.
Phorbol-12,13-dibutyrate
Product ID P2856
Cas No. 37558-16-0
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 37558-16-0 |
|---|---|
| Purity | ≥98% |
| Formula | C28H40O8 |
| Formula Wt. | 504.61 |
| IUPAC Name | [(1S,2S,6R,10S,11R,13S,14R,15R)-13-butanoyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] butanoate |
| Synonym | PDBu |
| Solubility | Soluble in DMSO or ethanol. |
| Appearance | Amorphous solid |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Aicart-Ramos C, Sánchez-Ruiloba L, Gómez-Parrizas M, et al. Protein kinase D activity controls endothelial nitric oxide synthesis. J Cell Sci. 2014 Aug 1;127(Pt 15):3360-72. PMID: 24928905.
Terui Y, Furukawa Y, Kikuchi J, et al. Apoptosis during HL-60 cell differentiation is closely related to a G0/G1 cell cycle arrest. J Cell Physiol. 1995 Jul;164(1):74-84. PMID: 7790399.
Rais S, Combadiere C, Hakim J, et al. Staurosporine up-regulates the expression of phorbol dibutyrate binding sites in human platelets. Biochem Pharmacol. 1994 May 18;47(10):1797-804. PMID: 8204096.