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Proteolipid protein (PLP, 139-151) is the immunodominant peptide fragment of PLP. This peptide is endogenously expressed in the central nervous system and is commonly used to induce experimental autoimmune encephalitis (EAE), an autoimmune disease similar to multiple sclerosis, in animal models.
| Cas No. | 122018-58-0 |
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| Purity | ≥95% |
| Formula | C72H104N20O17 |
| Formula Wt. | 1521.7 |
| Synonym | PLP |
| Solubility | Soluble in water (2 mg/mL). |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Soellner IA, Rabe J, Mauri V, et al. Differential aspects of immune cell infiltration and neurodegeneration in acute and relapse experimental autoimmune encephalomyelitis. Clin Immunol. 2013 Dec;149(3):519-29. PMID: 24239839.
Nicolò C, Sali M, Di Sante G, et al. Mycobacterium smegmatis expressing a chimeric protein MPT64-proteolipid protein (PLP) 139-151 reorganizes the PLP-specific T cell repertoire favoring a CD8-mediated response and induces a relapsing experimental autoimmune encephalomyelitis. J Immunol. 2010 Jan 1;184(1):222-35. PMID: 19949067.