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Prothionamide is an antibacterial compound that is clinically used to treat Mycobacterium-based diseases such as tuberculosis and leprosy. Prothionamide forms adducts with nicotinamide adenine dinucleotide (NAD), inhibiting InhA and preventing synthesis of mycoloic acids.
| Cas No. | 14222-60-7 |
|---|---|
| Purity | ≥98% |
| Formula | C9H12N2S |
| Formula Wt. | 180.27 |
| Chemical Name | 2-Propyl-4-pyridinecarbothioamide |
| IUPAC Name | 2-propylpyridine-4-carbothioamide |
| Synonym | Protionamide, Ektebin, Tuberex, Peteha, Trevintix |
| Melting Point | 142°C |
| Solubility | Soluble in ethanol and methanol. Slightly soluble in ether and chloroform. Insoluble in water. |
| Appearance | A Yellow Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Shim TS, Jo KW. Medical Treatment of Pulmonary Multidrug-Resistant Tuberculosis. Infect Chemother. 2013 Dec;45(4):367-374. PMID: 24475350.
Wang F, Langley R, Gulten G, et al. Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. PMID: 17227913.
Fajardo TT, Guinto RS, Cellona RV, et al. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74(3):457-61. PMID: 16525107.