• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Puromycin Dihydrochloride

Puromycin Dihydrochloride

Product ID P8168
Cas No. 58-58-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $58.00 In stock
25 mg $123.60 In stock
100 mg $420.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Puromycin is an aminonucleoside antibiotic compound originally produced by Streptomyces alboniger. Puromycin displays antibacterial activity through inhibition of ribosomal protein translation; it resembles the 3’ end of tRNA and is incorporated into growing protein chains through the ribosomal A site, inducing premature chain termination. Puromycin also induces DNA damage mediated by ROS and oxidative stress in animal models. In vitro, puromycin inhibits insulin-stimulated glycolysis by inhibiting insulin activation of phosphofructokinase 2. Puromycin also inhibits dipeptidyl peptidase II (DPP2; serine peptidase) and metallopeptidase. Additionally, this compound induces ERK activation-dependent apoptosis and mTOR-dependent autophagy in podocytes, leading to proteinuria and glomerular damage.

Product Info

Cas No.

58-58-2

Purity

≥98%

Formula

C22H29N7O5 • 2HCl

Formula Wt.

544.43

Chemical Name

(3'-[[(2S)-2-Amino-3-(4-methoxyphenyl)-1- oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine

IUPAC Name

(2S)-2-amino-N-[(2S,3S,4R, 5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3- yl]-3-(4-methoxyphenyl)propanamide

Synonym

Stylomycin Hydrochloride

Melting Point

175.5-177°C

Solubility

Soluble in water.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P8168 MSDS PDF

Info Sheet

P8168 Info Sheet PDF

References

Kang YL, Saleem MA, Chan KW, et al. The cytoprotective role of autophagy in puromycin aminonucleoside treated human podocytes. Biochem Biophys Res Commun. 2014 Jan 10;443(2):628-34. PMID: 24333414.

Liu S, Ding J, Fan Q, et al. The activation of extracellular signal-regulated kinase is responsible for podocyte injury. Mol Biol Rep. 2010 Jun;37(5):2477-84. PMID: 19728154.

Marshall CB, Pippin JW, Krofft RD, et al. Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney Int. 2006 Dec;70(11):1962-73. PMID: 17035936.

Probst I, Quentmeier A, Schweickhardt C, et al. Stimulation by insulin of glycolysis in cultured hepatocytes is attenuated by extracellular ATP and puromycin through purine-dependent inhibition of phosphofructokinase 2 activation. Eur J Biochem. 1989 Jun 15;182(2):387-93. PMID: 2525468.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L3250

    D-Limonene

    Terpene found in the rind of various citrus fru...

    ≥97%
  • M1646

    Melanin Concentrating Hormone, human/mouse/rat

    Endogenous peptide hormon involved in energy homeo...
    ≥98%
  • L5993

    Loxoprofen Sodium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B4796

    BLZ-945

    CSF-1R Inhibitor.

    ≥95%
  • R4132

    RKI-1447

    ROCK1/2 inhibitor.

    ≥98%
  • C0172

    Carbimazole

    Methimazole prodrug; thyroid peroxidase inhibit...

    ≥98%
  • T1605

    Tebuconazole

    Triazole; 14-α demethylase inhibitor, voltage-...

    ≥98%
  • O486188

    Omeprazole Impurity F and G mixture

    Regioisomers

    ≥98%
  • M1650

    Melanotan II

    Synthetis peptide, melanocortin analog; MCR ago...

    ≥98%
  • F465818

    Fluorouracil Impurity B

    Fluorouracil impurity

    ≥95%
  • N344784

    N-Nitroso Valsartan

    Valsartan impurity

    ≥98%
  • T0101

    7-epi-10-Deacetyltaxol

    Taxane found in Taxus; potential microtubule de...

    ≥98%
  • C0160

    Canrenone

    Metabolite of spironolactone; Na+/K+ ATPase par...

    ≥98%
  • B1655

    S-(N-Benzylthiocarbamoyl)-L-cysteine

    Cysteine conjugate of benzyl isothiocyanate (BI...

    ≥98%
  • M0368

    Marbofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • B1653

    Benzyl Isothiocyanate

    ITC found in cruciferous vegetables.

    ≥99%
  • P0008

    Pituitary Adenylate Cyclase-activating Peptide (6-38), human/sheep/rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • E8657

    Evodiamine

    Indole alkaloid found in Evodia rutaecarpa; top...

    ≥98%
  • C1649

    β-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • T0114

    Taxinin M

    Taxane found in Taxus; DNA polymerase inhibitor...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only