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Radicicol

Radicicol

Product ID R0212
Cas No. 12772-57-5
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $132.60 In stock
5 mg $571.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Radicicol is an analog of benzoquinone ansamycin that inhibits HSP90, Src family kinases, and Raf. Radicicol exhibits neuroprotective, antibiotic, antifungal, anti-parasitic, and antimalarial activities. In Plasmodium, radicicol targets topoisomerase VI-B, inhibiting mitochondrial replication. Radicicol also increases survival and neurite outgrowth of neurons in chick embryos.

Product Info

Cas No.

12772-57-5

Purity

≥96%

Formula

C18H17ClO6

Formula Wt.

364.78

Chemical Name

8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihyroxy-14- methyl-6H-oxireno[e][2]benzoxacyclotetradecin- 6,12(7H)-dione

IUPAC Name

(4R,6R,8R,9Z,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione

Synonym

Monorden, Monorderne

Melting Point

193.5°C

Solubility

Soluble in DMSO, methanol or ethanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R0212 MSDS PDF

Info Sheet

R0212 Info Sheet PDF

References

Chalapareddy S, Bhattacharyya MK, Mishra S, et al. Radicicol Confers Mid-Schizont Arrest by Inhibiting Mitochondrial Replication in Plasmodium falciparum. Antimicrob Agents Chemother. 2014 Aug;58(8):4341-4352. PMID: 24841259.

Gadelle D, Bocs C, Graille M, et al. Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol. Nucleic Acids Res. 2005 Apr 22;33(7):2310-7. PMID: 15849317.

Sano M, Yoshida M, Fukui S, et al. Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo. J Neurochem. 1999 Jun;72(6):2256-63. PMID: 10349833.

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