Reversine

Name: Reversine
SKU: R1885
Availability: BackOrder

Product ID R1885

Cas No. 656820-32-5

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Reversine is a purine analog that reverses or induces differentiation. Reversine displays anticancer chemotherapeutic and anti-metastatic activities; it transforms preadipocytes into mesenchymal stem cells, induces autophagy in thyroid cancer cells, and downregulates expression of miR-133a miRNA. This compound induces apoptosis and cell death in breast cancer cells. In animal models of cancer, reversine inhibits focal adhesion disassembly, decreases cell motility and invasion, and prevents tumor metastasis.

Product Info

Cas No.	656820-32-5
Purity	≥98%
Formula	C₂₁H₂₇N₇O
Formula Wt.	393.50
IUPAC Name	N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-3H-purine-2,6-diamine
Solubility	DMSO: 7mg/mL water: insoluble

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	R1885 MSDS PDF
Info Sheet	R1885 Info Sheet PDF

References

Kuo CH, Lu YC, Tseng YS, et al. Reversine induces cell cycle arrest, polyploidy, and apoptosis in human breast cancer cells. Breast Cancer. 2014 May;21(3):358-69. PMID: 22926505.

Park JG, Lee DH, Moon YS, et al. Reversine increases the plasticity of lineage-committed preadipocytes to osteogenesis by inhibiting adipogenesis through induction of TGF-β pathway in vitro. Biochem Biophys Res Commun. 2014 Mar 28;446(1):30-6. PMID: 24548409.

Kim M, Yi SA, Lee H, et al. Reversine induces multipotency of lineage-committed cells through epigenetic silencing of miR-133a. Biochem Biophys Res Commun. 2014 Feb 28;445(1):255-62. PMID: 24513286.

Bijian K, Lougheed C, Su J, et al. Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine. Br J Cancer. 2013 Nov 26;109(11):2810-8. PMID: 24169345.

Lu CH, Liu YW, Hua SC, et al. Autophagy induction of reversine on human follicular thyroid cancer cells. Biomed Pharmacother. 2012 Dec;66(8):642-7. PMID: 23089471.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Reversine

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

7-Hydroxyaristolochic Acid A

Deracoxib

Penitrem A

Angiotensin II (3-8), human

Moclobemide

T2 Toxin

Butein

Adefovir

Dipyridamole

Diclofenac Impurity C

Shikonin

Saikosaponin A

Amylin (8-37), rat

Monascorubrin

L-(+)-Ascorbic Acid

Usnic Acid

Clofibrate

Biapenem

S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione

α-Conotoxin GI

Footer