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Rifamycin is an ansamycin antibiotic that exhibits antibacterial and anti-inflammatory activities. Rifamycin inhibits bacterial DNA-dependent RNA polymerase, preventing formation of the initiation complex in transcription and suppressing RNA synthesis. Rifamycin displays efficacy against Mycobacterium, Clostridium, and Enterobacter. This compound also decreases LPS-stimulated cytokine synthesis in macrophages and cytokine secretion from CD4+ T cells in cellular models.
| Cas No. | 14897-39-3 |
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| Purity | ≥98% |
| Formula | C37H47NO12 • xNa |
| Formula Wt. | 719.75 |
| IUPAC Name | sodium;(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-acetyloxy-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-27-olate |
| Synonym | Rifamycin SV sodium salt, Rifamastene, Rifocin |
| Solubility | Soluble in water (pH7.2). |
| Appearance | Red Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Rosette C, Buendia-Laysa F Jr, Patkar S, et al. Anti-inflammatory and immunomodulatory activities of rifamycin SV. Int J Antimicrob Agents. 2013 Aug;42(2):182-6. PMID: 23756321.
Farrell DJ, Putnam SD, Biedenbach DJ, et al. In vitro activity and single-step mutational analysis of rifamycin SV tested against enteropathogens associated with traveler's diarrhea and Clostridium difficile. Antimicrob Agents Chemother. 2011 Mar;55(3):992-6. PMID: 21149623.
Campbell EA, Korzheva N, Mustaev A, et al. Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. PMID: 11290327.