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Rosiglitazone Maleate

Rosiglitazone Maleate

Product ID R5772
Cas No. 155141-29-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $71.70 In stock
100 mg $126.30 In stock
500 mg $233.60 In stock
1 g $340.30 In stock
5 g $875.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Rosiglitazone is a thiazolidinedione insulin sensitizer that activates PPARγ, decreasing blood glucose and insulin levels. Rosiglitazone exhibits anti-diabetic, anti-inflammatory, antioxidative, anticancer, anti-angiogenic, antihypertensive, and anti-fibrotic activities. In vivo, rosiglitazone decreases LPS-stimulated production of TNF-α, IL-1β, and IL-6 as well as activity of myeloperoxidase; it also inhibits activation of NF-κB, preventing mastitis. In multiple myeloma cells, rosiglitazone suppresses expression of HIF-1α and IGF-1, decreases activation of Aky, and Erk, and inhibits cell viability and proliferation. This compound also inhibits endothelin-1-induced vasoconstriction in a NO-dependent manner in animal models of pulmonary arterial hypertension. Additionally, rosiglitazone prevents activation of AP-1, production of collagen, and differentiation in fibroblasts.

Product Info

Cas No.

155141-29-0

Purity

≥98%

Formula

C18H19N3O3S • C4H4O4

Formula Wt.

473.51

Chemical Name

5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

IUPAC Name

(Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1, 3-thiazolidine-2,4-dione

Synonym

BRL-49653c, Avandia

Melting Point

122-123°C

Solubility

Readily soluble in ethanol and in buffered aqueous solutions with a pH of 2.3.

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R5772 MSDS PDF

Info Sheet

R5772 Info Sheet PDF

References

Rui M, Huang Z, Liu Y, et al. Rosiglitazone suppresses angiogenesis in multiple myeloma via downregulation of hypoxia inducible factor 1α and insulin like growth factor 1 mRNA expression. Mol Med Rep. 2014 Jul 22. [Epub ahead of print]. PMID: 25050627.

Mingfeng D, Xiaodong M, Yue L, et al. Effects of PPAR-γ Agonist Treatment on LPS-Induced Mastitis in Rats. Inflammation. 2014 May 18. [Epub ahead of print]. PMID: 24839089.

Liu Y, Tian XY, Huang Y, et al. Rosiglitazone Attenuated Endothelin-1-Induced Vasoconstriction of Pulmonary Arteries in the Rat Model of Pulmonary Arterial Hypertension via Differential Regulation of ET-1 Receptors. PPAR Res. 2014;2014:374075. PMID: 24701204.

He H, Tao H, Xiong H, et al. Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts. Toxicol Sci. 2014 Apr;138(2):468-81. PMID: 24449420.

Hou X, Zhang Y, Shen YH, et al. PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1. Eur J Pharmacol. 2013 Sep 5;715(1-3):196-203. PMID: 23791613.

Sharma AN, Elased KM, Lucot JB. Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice. J Psychopharmacol. 2012 May;26(5):724-732. PMID: 22331176.

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