• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Roxithromycin

Roxithromycin

Product ID R5992
Cas No. 80214-83-1
Purity ≥96%
Product Unit SizeCostQuantityStock
1 g $41.80 In stock
5 g $139.00 In stock
10 g $201.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Roxithromycin is a semi-synthetic macrolide antibiotic that exhibits anti-inflammatory, anti-asthma, vasodilatory, antibacterial, and anti-arthritic activities; it binds to the 50S ribosome, inhibiting protein synthesis. In animal models of ovalbumin-induced asthma, roxithromycin decreases the number of inflammatory cells and airway hyperresponsiveness and suppresses levels of IgE, inflammatory cytokines, and activated NF-κB. Roxithromycin also induces vascular relaxation ex vivo in arteries and thoracic aorta segments. In macrophages, this compound inhibits T cell production of TNF-α and IL-6; in animal models of arthritis, it inhibits T cell migration and decreases disease severity.

Product Info

Cas No.

80214-83-1

Purity

≥96%

Formula

C41H76N2O15

Formula Wt.

837.05

Chemical Name

Erythromycin 9-[-O-[(2-methoxyethoxy)methyl]- oxime]

IUPAC Name

(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[(2S,3R,4S, 6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12, 13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4, 6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11, 13-hexamethyl-oxacyclotetradecan-2-one

Synonym

Rulide, Surlid, Rotramin, Claramid, Overal, Rossitrol

Melting Point

115-120°C

Solubility

Soluble in HCl, and NaOH. Slightly soluble in alcohol and water. Soluble in chloroform (10 mg/mL).

Appearance

White or off-white crystal powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

R5992 MSDS PDF

Info Sheet

R5992 Info Sheet PDF

References

Ci X, Chu X, Xu X, et al. Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-κB activation in a mouse model of allergic asthma. Inflamm Res. 2012 Jul;61(7):749-58. PMID: 22481373.

Biava M, Porretta GC, Deidda D, et al. New trends in development of antimycobacterial compounds. Infect Disord Drug Targets. 2006 Jun;6(2):159-72. PMID: 16789877.

Urasaki Y, Nori M, Iwata S, et al. Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages. J Rheumatol. 2005 Sep;32(9):1765-74. PMID: 16142877.

Berman M, Hasdai D, Raanani E, et al. Ex-vivo effect of roxithromycin on human and rat arterial vasoactivity. Interact Cardiovasc Thorac Surg. 2005 Jun;4(3):232-7. PMID: 17670399.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F4583

    Flupirtine Maleate

    Kv7 K+ channel activator, NMDA antagonist, GABA...

    ≥98%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%
  • I1257

    Idoxuridine

    Nucleoside (deoxyuridine) analog; DNA chain ter...

    ≥98%
  • V1869

    Verbascoside

    Phenylpropanoid found in Castilleja, Verbena, V...

    ≥98%
  • O1179

    n-Octyl-4-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • I088240

    (S,S)-ICG-001

    Wnt/β-catenin inhibitor

    ≥98%
  • B8278

    Butoconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • D3302

    Diaveridine Hydrochloride

    Coccidiostat; dihydrofolate reductase inhibitor...

    ≥98%
  • M9710

    Mycophenolic Acid

    Phthalide; PPARγ agonist, IMPDH inhibitor, mic...

    ≥98%
  • B6807

    [Des-Arg9]-Bradykinin

    Natriuretic, vasodilatory peptide, bradykinin a...

    ≥95%
  • S6018

    Spectinomycin Dihydrochloride Pentahydrate

    Aminocyclitol; protein synthesis inhibitor.

    ≥603 µg/mg (potency)
  • H9812

    5-Hydroxytryptophol

    Serotonin/melatonin analog found in various pla...

    ≥98%
  • A5037

    Amiodarone Hydrochloride

    Voltage-gated Na+, Ca2+, K+ channel blocker, α...

    ≥98%
  • S8245

    Sulfadiazine

    Sulfonamide; folate production inhibitor.

    ≥98%
  • A5283

    [Sar1]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • D1874

    Desvenlafaxine Succinate Hydrate

    Venlafaxine metabolite; SERT and NET inhibitor....

    ≥99%
  • G7444

    GSK-1070916

    AurKB/C inhibitor.

    ≥98%
  • H1894

    Hexestrol

    Synthetic catechol; ER agonist, microtubule pol...

    ≥98%
  • G7200

    GS-967

    Na+ channel blocker.

    ≥98%
  • M1565

    S-Methyl-L-cysteine-S-oxide

    Organosulfur found in cruciferous vegetables; a...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only