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S-(−)-Warfarin >99%ee

S-(−)-Warfarin >99%ee

Product ID W0272
Cas No. 5543-57-7
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $153.10 In stock
5 mg $612.70 In stock
25 mg $1,939.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Warfarin is an orally available antithrombotic commonly used for preventing blood clot formation and migration. The S enantiomer of warfarin is somewhat more potent than the R enantiomer. This coumarin inhibits the subunit 1 of the vitamin K epoxide reductase complex (VKORC1), depleting the reduced form of vitamin K (KH2) and inhibiting the formation of coagulation factors II, VII, IX, and X. Warfarin has a relatively slow onset and requires 1 to 2 days to take effect. This compound is highly sensitive to a wide variety of genetic polymorphisms and is metabolized by cytochrome P4502C9; it also interacts with many other medications and foods, requiring diligent activity monitoring.

Product Info

Cas No.

5543-57-7

Purity

≥99%

Formula

C19H16O4

Formula Wt.

308.33

IUPAC Name

4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one

Synonym

(-)-Warfarin

Solubility

The solubility of (+)-warfarin in ethanol is approximately 5 mg/ml and approximately 25 mg/ml in DMSO and DMF

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

W0272 MSDS PDF

Info Sheet

W0272 Info Sheet PDF

Brochures

Warfarin Flyer

References

Hall AM, Wilkins MR. Warfarin: a case history in pharmacogenetics. Heart. 2005 May;91(5):563-4. PMID: 15831631.

Tabrizi AR, Zehnbauer BA, Borecki IB, et al. The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin. J Am Coll Surg. 2002 Mar;194(3):267-73. PMID: 11893129.

Freedman MD. Oral anticoagulants: pharmacodynamics, clinical indications and adverse effects. J Clin Pharmacol. 1992 Mar;32(3):196-209. PMID:1564123.

Wallin R, Martin LF. Vitamin K-dependent carboxylation and vitamin K metabolism in liver. Effects of warfarin. J Clin Invest. 1985 Nov;76(5):1879-84. PMID: 3932474.

Suttie JW. Mechanism of action of vitamin K: demonstration of a liver precursor of prothrombin. Science. 1973 Jan 12;179(4069):192-4. PMID: 4682251.

Custom Order

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