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S-Sulforaphane is a synthetic isothiocyanate. The R isomer of sulforaphane is found in broccoli. Sulforaphane is an inducer of phase II enzymes, displaying antioxidative and chemopreventive activities. It may inhibit the aryl hydrocarbon receptor (AhR).
| Cas No. | 155320-20-0 |
|---|---|
| Purity | ≥97% |
| Formula | C6H11NOS2 |
| Formula Wt. | 177.29 |
| Chemical Name | 1-Isothiocyanato-4[(S)-(methylsulfinyl)]-butane |
| IUPAC Name | 1-isothiocyanato-4-[(S)-methylsulfinyl]butane |
| Synonym | D-Sulforaphane; S(+)-sulforaphane |
| Solubility | Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. |
| Appearance | Slightly yellowish liquid |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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Holcombe L, Holman J, Hurd M, et al. Early life exposure to brocoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease. mSystems. 2023 Dec 21;8(6):e0068823. PMID: 37942948.
Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862.
Abdull Razis AF, Bagatta M, De Nicola GR, et al. Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Arch Toxicol. 2011 Aug;85(8):919-27. PMID: 21132492.
Christine A. Houghton, Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 2716870, 27 pages https://doi.org/10.1155/2019/2716870