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Saikosaponin D

Saikosaponin D

Product ID S0134
Cas No. 20874-52-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $388.80 In stock
5 mg $777.70 In stock
Bulk Quote

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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells.

Product Info

Cas No.

20874-52-6

Purity

≥98%

Formula

C42H68O13

Formula Wt.

780.98

IUPAC Name

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-3,5-dihydroxy-2-[[(1S,2R,4S,5R,8R,9R,10S,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyloxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Synonym

Saikosaponin

Melting Point

212-218°C

Solubility

Soluble in DMSO or methanol.

Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0134 MSDS PDF

Info Sheet

S0134 Info Sheet PDF

References

Zhang BZ, Guo XT, Chen JW, et al. Saikosaponin-D Attenuates Heat Stress-Induced Oxidative Damage in LLC-PK1 Cells by Increasing the Expression of Anti-Oxidant Enzymes and HSP72. Am J Chin Med. 2014 Aug 29:1-17. [Epub ahead of print] PMID: 25169909.

Ying ZL, Li XJ, Dang H, et al. Saikosaponin-d affects the differentiation, maturation and function of monocyte-derived dendritic cells. Exp Ther Med. 2014 May;7(5):1354-1358. PMID: 24940438.

Wong VK, Li T, Law BY, et al. Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells. Cell Death Dis. 2013 Jul 11;4:e720. PMID: 23846222.

Lu XL, He SX, Ren MD, et al. Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: involvement of CCAAT/enhancer binding protein β and cyclooxygenase-2. Mol Med Rep. 2012 Mar;5(3):637-44. PMID: 22159471.

Zheng JX, Lu KQ, Xia DG, et al. Therapeutic effects and mechanism of saikosaponin-d in mice with bleomycin-induced pulmonary fibrosis. Zhonghua Yi Xue Za Zhi. 2010 Mar 30;90(12):808-12. PMID: 20450618.

Wang BF, Cheng YA, Dang SS. Angiogenesis inhibitory effect of saikosaponin-d on chicken embryo. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 May;29(5):425-9. PMID: 19673334.

Chiang LC, Ng LT, Liu LT, et al. Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species. Planta Med. 2003 Aug;69(8):705-9. PMID: 14531019.

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