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Salsalate

Salsalate

Product ID S0244
Cas No. 552-94-3
Purity ≥95%
Product Unit SizeCostQuantityStock
25 g $61.10 In stock
100 g $204.30 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Salsalate is s prodrug of salicylic acid composed of two salicylate molecules attached by an ester bond. Salsalate acts as a non-steroidal anti-inflammatory drug (NSAID), producing weak, reversible inhibition of COX-1 and COX-2. Salsalate primarily acts as an analgesic, but also exhibits anti-diabetic activity as well. Salsalate decreases blood glucose levels and increases adiponectin levels. This compound also inhibits expression of insulin resistance-inducing Selenoprotein P, potentially mediated by activation of AMPK and phosphorylation of Foxo1α. Salsalate acts as an anti-inflammatory in the treatment of rheumatoid arthritis, as it inhibits IκB kinase and activation of NF-κB. Additionally, salsalate improves glucose tolerance and downregulates 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity in visceral adipose in clinical and in vivo settings.

Product Info

Cas No.

552-94-3

Purity

≥95%

Formula

C14H10O5

Formula Wt.

258.23

Chemical Name

2-(2-hydroxybenzoyl)oxybenzoic acid

IUPAC Name

2-(2-hydroxybenzoyl)oxybenzoic acid

Synonym

salicylsalicylic acid, disalicylic acid, sasapyrine

Melting Point

147°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S0244 MSDS PDF

Info Sheet

S0244 Info Sheet PDF

References

Jung TW, Choi HY, Lee SY, et al. Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1α Pathway. PLoS One. 2013 Jun 18;8(6):e66529. PMID: 23825542.

Nixon M, Wake DJ, Livingstone DE, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012 Apr;61(4):790-6. PMID: 22357964.

McCarty MF. Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome. Med Hypotheses. 2010 Sep;75(3):276-81. PMID: 20080359.

Custom Order

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