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Satraplatin

Satraplatin

Product ID S0278
Cas No. 129580-63-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $337.10 In stock
10 mg $540.80 In stock
50 mg $1,735.80 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Satraplatin is a platinum-based anticancer chemotherapeutic that is used in cisplatin-resistant cancers; like other platinum compounds, it forms DNA adducts and inhibits DNA repair. Satraplatin induces G2/M phase cell cycle arrest, inhibiting the proliferation of oral squamous cell carcinoma cells. Satraplatin also upregulates expression of p21 and cyclin B1 and increases caspase- and Fas-mediated apoptosis in colorectal cancer cells.

Product Info

Cas No.

129580-63-8

Purity

≥98%

Formula

C10H22Cl2N2O4Pt

Formula Wt.

498.26

Chemical Name

(OC-6-43)-bis(acetato-O)amminedichloro(cyclohexanamine)-platinum

Synonym

Poplat

Solubility

Soluble in DMSO.

Appearance

Light yellow crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0278 MSDS PDF

Info Sheet

S0278 Info Sheet PDF

References

Figg WD, Chau CH, Madan RA, et al. Phase II study of satraplatin and prednisone in patients with metastatic castration-resistant prostate cancer: a pharmacogenetic assessment of outcome and toxicity. Clin Genitourin Cancer. 2013 Sep;11(3):229-37. PMID: 23684781.

Kalimutho M, Minutolo A, Grelli S, et al. Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance. Cancer Chemother Pharmacol. 2011 Jun;67(6):1299-312. PMID: 20734047.

Yamano Y, Shiiba M, Negoro K, et al. Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells. Head Neck. 2011 Mar;33(3):309-17. PMID: 20848452.

Fokkema E, Groen HJ, Helder MN, et al. JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin. Biochem Pharmacol. 2002 Jun 1;63(11):1989-96. PMID: 12093475.

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