• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
SB-590885

SB-590885

Product ID S0459
Cas No. 405554-55-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $214.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SB-590885 is a triarylimidazole that selectively inhibits Raf kinase and is a particularly potent inhibitor of B-Raf. SB-590885 exhibits anticancer chemotherapeutic activity through its ability to stabilize the oncogenic B-Raf kinase domain in an active configuration, therefore inhibiting downstream MAPK activation. SB-590885 also limits tissue damage after cerebral ischemia, displaying neuroprotective benefit.

Product Info

Cas No.

405554-55-4

Purity

≥97%

Formula

C27H27N5O2

Formula Wt.

453.54

Chemical Name

(E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime

IUPAC Name

N,N-dimethyl-2-[4-[(4Z)-4-(1-nitroso-2, 3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl] phenoxy]ethanamine

Solubility

DMSO 5 mg/mL (11.02 mM) Water Insoluble Ethanol Insoluble

Appearance

Light yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0459 MSDS PDF

Info Sheet

S0459 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Ahnstedt H, Säveland H, Nilsson O, et al. Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway. BMC Neurosci. 2011 Jan 11;12:5. PMID: 21223556.

King AJ, Patrick DR, Batorsky RS, et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 2006 Dec 1;66(23):11100-5. PMID: 17145850.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M3476

    Mithramycin

    Polyketide; DNMT 1 inhibitor, RNA synthesis inh...

    ≥98%
  • V1668

    Vemurafenib

    B-Raf inhibitor.

    ≥98%
  • I4961

    Imperatorin

    Furocoumarin; voltage-gated Na+ channel blocker...

    ≥98%
  • G4797

    GLYX-13 Trifluoroacetate

    Peptide; NMDA partial agonist.

    ≥98%
  • N1755

    Neomycin Sulfate

    Polycationic aminoglycoside; protein translatio...

    ≥98%
  • U6956

    Uroguanylin, human

    Endogenous peptide, involved in water/Na+ homeo...

    ≥95%
  • T1679

    Tetracycline Hydrochloride

    Polyketide; protein translation inhibitor, mamm...

    ≥95%
  • S8251

    Sulfluramid

    Perfluorinated insecticide.

    ≥95%
  • D490280

    DMH-1

    Inhibitor of BMP.

    ≥99%
  • A9912

    AZD-7762 Hydrochloride

    CHK1 inhibitor.

    ≥98%
  • N3584

    Nivalenol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥98%
  • D1749

    Demecolcine

    Used to study embryonic cloning; microtubule po...

    ≥97%
  • P698574

    Prolylrapamycin

    Rapamycin analog

  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodr...

    ≥98%
  • A5056

    Amorolfine Hydrochloride

    14α-demethylase inhibitor.

    ≥98.5%
  • O9458

    Oxolinic Acid

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • T982698

    L-Tyrosine disodium salt

    Amino acid precursor of dopamine.

    ≥98%
  • L3550

    Limonin

    Furanolactone found in citrus fruits.

    ≥98%
  • C9610

    D-Cycloserine

    NMDA partial agonist, D-Ala-D-Ala ligase inhibi...

    ≥98%
  • H9718

    2-Hydroxyflutamide

    Non-steroid; AR antagonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only