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Scriptaid

Scriptaid

Product ID S1069
Cas No. 287383-59-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $152.70 In stock
5 mg $587.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Scriptaid is an inhibitor of histone deacetylases that exhibits anticancer activity. In non-small cell lung cancer (NSCLC) cells, scriptaid downregulates expression of Chk1. In glioma cells, scriptaid increases activation of JNK and p38 MAPK, expression of p21 and p27, and activity of Ras; it also decreases activity of telomerase, inducing apoptosis and decreasing proliferation. In somatic cell nuclear transfer, scriptaid improves the quality of cloned mouse embryos.

Product Info

Cas No.

287383-59-9

Purity

≥98%

Formula

C18H18N2O4

Formula Wt.

326.35

Chemical Name

6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)- hexanoic acid hydroxyamide

IUPAC Name

6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide

Synonym

CGK1026, Scriptide

Solubility

Soluble in DMSO (1mg/mL) or methanol.

Appearance

Off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S1069 MSDS PDF

Info Sheet

S1069 Info Sheet PDF

References

Bui HT, Seo HJ, Park MR, et al. Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. Biol Reprod. 2011 Nov;85(5):1048-56. PMID: 21753193.

Brazelle W, Kreahling JM, Gemmer J, et al. Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. PLoS One. 2010 Dec 14;5(12):e14335. PMID: 21179472.

Sharma V, Koul N, Joseph C, et al. HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. J Cell Mol Med. 2010 Aug;14(8):2151-61. PMID: 19583803.

Custom Order

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