Sertraline Hydrochloride

Name: Sertraline Hydrochloride
SKU: S1971
Availability: InStock

Product ID S1971

Cas No. 79559-97-0

Purity ≥98%

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Description

Sertraline exhibits antidepressant and anxiolytic activities; it is a typical selective serotonin reuptake inhibitor (SSRI). Sertraline primarily inhibits the 5-HT transporter (SERT), but also inhibits the dopamine transporter (DAT), α1-adrenergic receptors, and potentially σ1 receptors. Additionally, sertraline inhibits osteoclast formation and resorption and induces apoptosis in both osteoclasts and osteoblasts. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	79559-97-0
Purity	≥98%
Formula	C₁₇H₁₇Cl₂N • HCl
Formula Wt.	342.70
Chemical Name	(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
IUPAC Name	(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3, 4-tetrahydronaphthalen-1-amine;hydrochloride
Synonym	Lustral, Zoloft
Melting Point	243-245°C
Solubility	Slightly soluble in water and isopropyl alcohol. Sparingly soluble in ethanol.
Appearance	A White to Off-White Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	S1971 MSDS PDF
Info Sheet	S1971 Info Sheet PDF

References

Santos-Cruz L, Campos-Aguilar M, Castaneda-Partida L, et al. Impact of larval sertraline exposure on alternative splicing in neural tissue of adult Drosophila melanogaster. Int J Mol Sci. 2025 Jan 10;26(2):563. PMID: 39859278.

Guaiana G, Gupta S, Chiodo D, et al. Agomelatine versus other antidepressive agents for major depression. Cochrane Database Syst Rev. 2013 Dec 17;12:CD008851. PMID: 24343836.

Zhu H, Bogdanov MB, Boyle SH, et al. Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. PMID: 23874572.

Hodge JM, Wang Y, Berk M, et al. Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiatry. 2013 Jul 1;74(1):32-9. PMID: 23260229.

Meyer JH, Wilson AA, Sagrati S, et al. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psychiatry. 2004 May;161(5):826-35. PMID: 15121647.

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Sertraline Hydrochloride

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