Description
Shikonin is a natural naphthoquinone compound. It has anti-inflammatory, antibacterial, anti-tumor, and hypoglycemic activities. It has also been shown to induce necroptosis and chromatinolysis in glioma cells.
Product Unit Size | Cost | Quantity | Stock |
---|
Shikonin is a natural naphthoquinone compound. It has anti-inflammatory, antibacterial, anti-tumor, and hypoglycemic activities. It has also been shown to induce necroptosis and chromatinolysis in glioma cells.
Cas No. | 517-89-5 |
---|---|
Purity | ≥98% |
Formula | C16H16O5 |
Formula Wt. | 288.29 |
Chemical Name | R(-)-Shikonin |
IUPAC Name | 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione |
Synonym | Isoarnebin 4, (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione, (-)-Shikonin |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Zhao Z, Zhu Q, Zhou X, et al. Structural basis for the inhibition of SARS-CoV-2 Mpro D48N mutant by shikonin and PF-07321332. Viruses. 2023 Dec 30;16(1):65. PMID: 38257765.
Huang B, Wang Q, Jiang L, et al. Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages. Front Pharmacol. 2022 Aug 17;13:926945. PMID: 36059938.
Maeoka R, Ouji Y, Nakazawa T, et al. Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance. Biomed Pharmacother. 2023 Oct;166:115296. PMID: 37557011.
Wang X, Fan L, Wang X, et al. Cyclophilin A contributes to shikonin-induced glioma cell necroptosis and promotion of chromatinolysis. Sci Rep. 2022 Aug 29;12(1):14675. PMID: 36038617.
Xu Z, Huang L, Zhang T, et al. Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3beta signalling. Oncol Lett. 2022 Jul 8;24(3):304. PMID: 35949620.
Sulforaphane homolog, ITC found in cruciferous ...
Coumarin, more potent isomer; VKORC1 inhibitor....
Endogenous neuropeptide, involved in opioid sig...
α2-adrenergic agonist.
EZH2 HMT inhibitor.
CRM1/XPO1 inhibitor.
Immunodominant peptide epitope occurring in mul...
B-Raf and c-Raf inhibitor.
Mesalazine derivative, sulfa drug; sepiapterin ...
ITC, radical scavenger.
Synthetic isoflavone.
Read-through agent and nonsense mutation target...
Tyrosine kinase inhibitor.
Synthetic kahweol derivative.
Triterpene saponin found in species of Panax.
Natriuretic, vasodilatory peptide, bradykinin a...
Impurity of diclofenac
Endogenous peptide, produced by activation of P...
Endogenous sterol component of animal cell memb...