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Shikonin

Shikonin

Product ID S291333
Cas No. 517-89-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $64.90 In stock
50 mg $214.10 In stock
100 mg $382.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Shikonin is a natural naphthoquinone compound. It has anti-inflammatory, antibacterial, anti-tumor, and hypoglycemic activities. It has also been shown to induce necroptosis and chromatinolysis in glioma cells.

Product Info

Cas No.

517-89-5

Purity

≥98%

Formula

C16H16O5

Formula Wt.

288.29

Chemical Name

R(-)-Shikonin

IUPAC Name

5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione

Synonym

Isoarnebin 4, (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione, (-)-Shikonin

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S291333 MSDS PDF

Info Sheet

S291333 Info Sheet PDF

References

Zhao Z, Zhu Q, Zhou X, et al. Structural basis for the inhibition of SARS-CoV-2 Mpro D48N mutant by shikonin and PF-07321332. Viruses. 2023 Dec 30;16(1):65. PMID: 38257765.

Huang B, Wang Q, Jiang L, et al. Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages. Front Pharmacol. 2022 Aug 17;13:926945. PMID: 36059938.

Maeoka R, Ouji Y, Nakazawa T, et al. Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance. Biomed Pharmacother. 2023 Oct;166:115296. PMID: 37557011.

Wang X, Fan L, Wang X, et al. Cyclophilin A contributes to shikonin-induced glioma cell necroptosis and promotion of chromatinolysis. Sci Rep. 2022 Aug 29;12(1):14675. PMID: 36038617.

Xu Z, Huang L, Zhang T, et al. Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3beta signalling. Oncol Lett. 2022 Jul 8;24(3):304. PMID: 35949620.

Custom Order

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