• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Sphingosine-1-Phosphate

Sphingosine-1-Phosphate

Product ID S6130
Cas No. 26993-30-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $280.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sphingosine-1-phosphate (S1P) is an endogenous signaling sphingolipid produced from metabolism of ceramides. S1P binds the S1P receptor and may inhibit HDACs. S1P exhibits neuroprotective activity as well as both pro-inflammatory and anti-inflammatory properties, depending on the model. S1P increases neuron viability and upregulates expression of Bcl-2 and Bcl-xl, inhibiting glucose deprivation stress. S1P upregulates expression of PAR4, promoting cell migration and COX-2 expression in vitro. Clinically, S1P preserves fertility and gonadal function in subjects exposed to cytotoxic agents such as chemotherapeutic compounds.

Product Info

Cas No.

26993-30-6

Purity

≥98%

Formula

C18H38NO5P

Formula Wt.

379.47

Chemical Name

4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-

IUPAC Name

[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate InChI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16- 24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22, 23)/b15-14+/t17-,18+/m0/s1

Synonym

D-erythro-Sphingosine-1-phosphate

Melting Point

155°C

Solubility

Soluble in methanol.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S6130 MSDS PDF

Info Sheet

S6130 Info Sheet PDF

References

Czubowicz K, Cieślik M, Pyszko J, et al. Sphingosine-1-Phosphate and Its Effect on Glucose Deprivation/Glucose Reload Stress: From Gene Expression to Neuronal Survival. Mol Neurobiol. 2014 Jul 24. [Epub ahead of print]. PMID: 25056275.

Mahajan-Thakur S, Sostmann BD, Fender AC, et al. Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. J Leukoc Biol. 2014 Jul 2. [Epub ahead of print]. PMID: 24990321.

Nguyen-Tran DH, Hait NC, Sperber H, et al. Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. Dis Model Mech. 2014 Jan;7(1):41-54. PMID: 24077965.

Zelinski MB, Murphy MK, Lawson MS, et al. In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates. Fertil Steril. 2011 Mar 15;95(4):1440-5.e1-7. PMID: 21316047.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • V1871

    Veratridine

    Binds to neurotoxin receptor site 2 on voltage-...

    ≥98%
  • S3568

    Siramesine

    σ2 agonist.

    ≥98%
  • A6002

    Apamin

    Peptide, bee venom toxin; SK2/3/4 K+ channel bl...

    ≥95%
  • L8276

    Luteinizing Hormone Releasing Hormone

    Endogenous peptide hormone; GnRH agonist.

    ≥98%
  • A8070

    Auraptene

    Monoterpene coumarin ether found in Citrus; PPA...

    ≥98%
  • Z5653

    Zonisamide

    Sulfonamide; carbonic anhydrase inhibitor, volt...

    ≥96%
  • D3429

    Dihydrocytochalasin B

    Mycotoxin derivative; actin polymerization inhi...

    ≥98%
  • L302690

    LHRH Acetate Salt

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • R0272

    Rasagiline Mesylate

    MAO-A/B inhibitor.

    ≥98%
  • P2522

    S-(N-Phenylthiocarbamoyl)-glutathione

    Glutathione-ITC conjugate, antioxidant.

    ≥98%
  • U0618

    Ubenimex

    Dipeptide; aminopeptidase (N/CD13) inhibitor.

    ≥98%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.

    ≥98%
  • A7578

    Astragaloside IV

    Found in Astragalus membranaceus.

    ≥98%
  • A4441

    Allicin, aqueous solution

    Organosulfur found in garlic; Kir K+ channel ac...

    ≥98%
  • S9754

    Syntide 2

    Synthetic peptide, CDPK, PKC, CaMKII substrate....

    ≥95%
  • T2817

    Theophylline

    Methylxanthine; PDE inhibitor, A1/2 adenosine a...

    ≥98%
  • A001001

    A 83-01

    TGFbeta receptor inhibitor

    ≥98%
  • P3348

    Pimecrolimus

    Calcineurin inhibitor, potential TRPV1 agonist....

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only