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SRPIN340

SRPIN340

Product ID S7061
Cas No. 218156-96-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $126.50 In stock
25 mg $489.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SRPIN340 inhibits serine-arginine-rich protein kinase 1 (SRPK1), exhibiting antiviral, anti-angiogenic, and anticancer chemotherapeutic activities. In vitro, SRPIN340 inhibits replication of hepatitis C virus (HCV). In animal models of melanoma, this compound decreases expression of VEGF and suppresses tumor growth. SRPIN340 also prevents pathological retinal neovascularization in vivo.

Product Info

Cas No.

218156-96-8

Purity

≥98%

Formula

C18H18F3N3O

Formula Wt.

349.36

Chemical Name

N-(2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide

IUPAC Name

N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide

Synonym

SRPIN 340

Solubility

DMSO: ≥ 42 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S7061 MSDS PDF

Info Sheet

S7061 Info Sheet PDF

References

Gammons MV, Lucas R, Dean R, et al. Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma. Br J Cancer. 2014 Jul 29;111(3):477-85. PMID: 25010863.

Gammons MV, Dick AD, Harper SJ, et al. SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2013 Aug 27;54(8):5797-806. PMID: 23761094.

Karakama Y, Sakamoto N, Itsui Y, et al. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 2010 Aug;54(8):3179-86. PMID: 20498328.

Custom Order

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