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Stavudine

Stavudine

Product ID S7603
Cas No. 3056-17-5
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $52.50 In stock
250 mg $105.00 In stock
1 g $273.00 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Stavudine is a nucleoside analog of thymidine that exhibits antiviral activity. Stavudine is an inhibitor of reverse transcriptase that intercalates with DNA to inhibit viral replication and growth. Administration of stavudine may increase levels of ROS and mitochondrial dysfunction in adipocytes, leading to apoptosis and decreases in proliferation. Stavudine induces autophagy in adipocytes as well, resulting in lipid accumulation and hepatic dysfunction.

Product Info

Cas No.

3056-17-5

Purity

≥99%

Formula

C10H12N2O4

Formula Wt.

224.21

Chemical Name

1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

IUPAC Name

1-[(2R,5S)-5-(hydroxymethyl)-2, 5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

Synonym

d4T

Melting Point

159-160°C

Solubility

Water

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S7603 MSDS PDF

Info Sheet

S7603 Info Sheet PDF

Brochures

Antivirals Booklet

References

Sandhya B, Seetharamappa J. Probing the site-selective binding of an antiretroviral drug, Stavudine to calf thymus DNA. Nucleosides Nucleotides Nucleic Acids. 2013;32(12):660-9. PMID: 24328563.

Stankov MV, Panayotova-Dimitrova D, Leverkus M, et al. Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes. Antimicrob Agents Chemother. 2013 Jan;57(1):543-51. PMID: 23147731.

Stankov MV, Panayotova-Dimitrova D, Leverkus M, et al. Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation. AIDS. 2012 Oct 23;26(16):1995-2006. PMID: 22914580.

Naeger LK, Margot NA, Miller MD. ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 2002 Jul;46(7):2179-84. PMID: 12069972.

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