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SU-1498 is a tyrphostin inhibitor of VEGFR that exhibits anticancer chemotherapeutic and anti-angiogenic activities. In vivo, SU-1498 inhibits angiogenesis, preventing VEGF-induced renal development and VEGFR2-mediated neurogenesis. SU-1498 also inhibits signal transmission from Akt, ERK1/2, Src, and STAT, decreasing phosphorylation of EGFRs and inhibiting autocrine growth and viability of cells.
| Cas No. | 168835-82-3 |
|---|---|
| Purity | ≥99% |
| Formula | C25H30N2O2 |
| Formula Wt. | 390.5 |
| Chemical Name | (E)-N-(3-Phenylpropyl)-a-cyano-3’,5’-diisopropyl-4’-hydroxycinnamamide |
| IUPAC Name | (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide |
| Solubility | DMSO (25mg/ml), Ethanol (20mg/ml) |
| Appearance | Yellow Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ligęza J, Ligęza J, Klein A. Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells. Acta Biochim Pol. 2011;58(3):391-6. PMID: 21887406.
Lu KT, Sun CL, Wo PY, et al. Hippocampal neurogenesis after traumatic brain injury is mediated by vascular endothelial growth factor receptor-2 and the Raf/MEK/ERK cascade. J Neurotrauma. 2011 Mar;28(3):441-50. PMID: 21091268
Lee SJ, Cho SJ, Ju SY, et al. Effect of retinoic acid on renal development in newborn mice treated with an angiogenesis inhibitor. Pediatr Int. 2010 Jun;52(3):386-92. PMID: 19761519
Boguslawski G, McGlynn PW, Harvey KA, et al. SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro. J Biol Chem. 2004 Feb 13;279(7):5716-24. PMID: 14625306.