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Tebuconazole is a triazole pesticide/fungicide with broad antifungal activity. Like many azole fungicides, tebuconazole likely inhibits 14-α demethylase, inhibiting ergosterol production and fungal cell wall synthesis. Additionally, tebuconazole may inhibit aromatase and act as an endocrine disrupter. Tebuconazole also acts as a nonspecific inhibitor of voltage-gated Ca2+ channels in PC12 neurons, modulating intracellular Ca2+ levels.
| Cas No. | 107534-96-3 |
|---|---|
| Purity | ≥98% |
| Formula | C16H22ClN3O |
| Formula Wt. | 307.82 |
| IUPAC Name | 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol |
| Melting Point | 102 |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Heusinkveld HJ, Molendijk J, van den Berg M, et al. Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. Toxicol Sci. 2013 Aug;134(2):374-81. PMID: 23708404.
Kjærstad MB, Taxvig C, Nellemann C, et al. Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals. Reprod Toxicol. 2010 Dec;30(4):573-82. PMID: 20708073.
Taxvig C, Vinggaard AM, Hass U, et al. Endocrine-disrupting properties in vivo of widely used azole fungicides. Int J Androl. 2008 Apr;31(2):170-7. PMID: 18067565.
Taxvig C, Hass U, Axelstad M, et al. Endocrine-disrupting activities in vivo of the fungicides tebuconazole and epoxiconazole. Toxicol Sci. 2007 Dec;100(2):464-73. PMID: 17785682.
Sanderson JT, Boerma J, Lansbergen GW, et al. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 2002 Jul 1;182(1):44-54. PMID: 12127262.