Thyrotropin-releasing Hormone

Name: Thyrotropin-releasing Hormone
SKU: T3101
Availability: InStock

Product ID T3101

Cas No. 24769-58-2

Purity ≥95%

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Description
Product Info
Shipping and Storage
Downloads
References

Description

Thyrotropin-releasing hormone (TRH) is an endogenous tripeptide that acts as a neurotransmitter and neurohormone. TRH regulates hypothalamic-pituitary-adrenal (HPA) and estrogenic signaling pathways. TRH exhibits immunomodulatory and neuroprotective activities. TRH prevents oxidative stress, caspase-mediated apoptosis, glutamate toxicity, and neuroinflammation. Additionally, TRH stimulates epidermal regeneration in ex vivo models, increasing would healing. TRH activates the TRH receptor.

Product Info

Cas No.	24769-58-2
Purity	≥95%
Formula	C₁₆H₂₂N₆O₄
Formula Wt.	362.4
IUPAC Name	(2S)-1-[(2S)-3-(4H-imidazol-4-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
Synonym	TRH, Thyrotropin-releasing factor, TRF, Protirelin, Thyroliberin
Solubility	Soluble in DMSO.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T3101 MSDS PDF
Info Sheet	T3101 Info Sheet PDF

References

Fekete C, Lechan RM. Central Regulation of Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions. Endocr Rev. 2013 Dec 4:er20131087. [Epub ahead of print]. PMID: 24423980.

Pekary AE, Sattin A. Increased TRH and TRH-like peptide release in rat brain and peripheral tissues during proestrus/estrus. Peptides. 2013 Dec 1;52C:1-10. PMID: 24296042.

Daimon CM, Chirdon P, Maudsley S, et al. The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases. Am J Alzheimers Dis (Columbia). 2013;1(1). PMID: 24199031.

Meier NT, Haslam IS, Pattwell DM, et al. Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin. PLoS One. 2013 Sep 2;8(9):e73596. PMID: 24023889.