Description
Topotecan is an anticancer chemotherapeutic compound that inhibits topoisomerase I and is clinically used to treat various cancers. Topotecan induces apoptosis in retinocytoma cells and ovarian cancer cells.
Topotecan Hydrochloride
Product ID T5761
Cas No. 119413-54-6
Purity ≥97%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 119413-54-6 |
|---|---|
| Purity | ≥97% |
| Formula | C23H25N3O5 • HCl |
| Formula Wt. | 457.91 |
| Chemical Name | (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]- quinoline-3,14(4H,12H)-dione hydrochloride |
| IUPAC Name | (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride |
| Synonym | Hycamtin, NSC-609669, SKF-104864A |
| Melting Point | 213-218°C(dec.) |
| Solubility | Soluble in methanol, water (92 mg/mL at 25 °C), DMSO (92 mg/mL at 25 °C), ethanol (<1 mg/mL at 25 °C), and 1: 1 solution of DMSO: PBS (pH 7.2, ~0.5 mg/mL). |
| Appearance | Pale Yellow Crystal Powder |
Shipping and Storage
| Store Temp | Ambient |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Attia SM, Ahmad SF, Abd-Ellah MF, et al. Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study. Food Chem Toxicol. 2013 Dec;62:470-4. PMID: 24036143.
Zhang M, Shan BE, Yuan NF, et al. Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chin Med J (Engl). 2013 Jan;126(2):340-4. PMID: 23324287.
Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.
Sonabend AM, Stuart RM, Yun J, et al. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump. Neuro Oncol. 2011 Aug;13(8):886-893. PMID: 21750007.