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Torsemide

Torsemide

Product ID T5968
Cas No. 56211-40-6
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $102.00 In stock
250 mg $204.30 In stock
1 g $612.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Torsemide is a pyridine-sulfonyl urea loop diuretic known for its antihypertensive and cardioprotective activities. This compound acts as a competitive inhibitor of the Na+-K+-2Cl- symporter in the loop of Henle by binding directly to the Cl- binding site; this inhibition prevents reabsorption of Na+, Cl-, Mg2+, and Ca2+, resulting in a decrease in blood volume and pressure. Torsemide treats edema, hypertension, and congestive heart failure, attenuating left ventricular cardiac remodeling. This compound also inhibits aldosterone secretion and ATPase activity of HSP90.

Product Info

Cas No.

56211-40-6

Purity

≥99%

Formula

C16H20N4O3S

Formula Wt.

348.42

Chemical Name

N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide

IUPAC Name

1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea

Synonym

Torasemide

Solubility

DMSO 18 mg/mL Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T5968 MSDS PDF

Info Sheet

T5968 Info Sheet PDF

References

Sheikha GA, Al-Sha'er MA, Taha MO. Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2011 Oct;26(5):603-9. PMID: 21190426.

Kasama S, Toyama T, Hatori T, et al. Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart. 2006 Oct;92(10):1434-40. PMID: 16621879.

Goodfriend TL, Ball DL, Oelkers W, et al. Torsemide inhibits aldosterone secretion in vitro. Life Sci. 1998;63(3):PL45-50. PMID: 9698054.

Lupinacci L, Puschett JB. An examination of the site and mechanism of action of torasemide in man. J Clin Pharmacol. 1988 May;28(5):441-7. PMID: 3392242.

Recasens M, Pin JP, Bockaert J. Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes. Neurosci Lett. 1987 Feb 24;74(2):211-6. PMID: 2883610.

Custom Order

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