LKT Labs

Biochemicals for Life Science Research

Transactivator of Transcription Peptide (2-4)

Transactivator of Transcription Peptide (2-4)

Product ID T0077
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $123.00 In stock
1 mg $210.00 In stock
2.5 mg $368.00 Please Inquire
Bulk Quote

Quicklinks

Description

Transactivator of transcription (TAT) protein is produced by HIV-1 and is involved in the induction of HIV-associated neurologic disorders (HAND). TAT is a neurotoxin that infects neurons, which HIV is unable to do. In neurons, TAT increases the number of inhibitory synapses and decreases the number of excitatory synapses in a Ca2+-dependent manner. TAT also activates microglia and other myeloid cells, disrupting cytokine/chemokine homeostasis and inducing neuroinflammation. This peptide sequence (YGRKKRRQRRRGYGRKKRRQRRRG) represents two back-to-back protein transduction (cell-penetrating) domains of TAT.

Product Info

Purity

≥95%
Formula

C132H240N66O29
Formula Wt.

3215.81
Synonym

TAT 2-4, TAT peptide, YGRKKRRQRRRGYGRKKRRQRRRG
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T0077 MSDS PDF
Info Sheet

T0077 Info Sheet PDF

References

Hargus NJ, Thayer SA. Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture. J Neurosci. 2013 Nov 6;33(45):17908-20. PMID: 24198379.

Bethel-Brown C, Yao H, Callen S, et al. HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1. J Immunol. 2011 Apr 1;186(7):4119-29. PMID: 21368226.

Lu SM, Tremblay MÈ, King IL, et al. HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One. 2011;6(9):e23915. PMID: 21912650.

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