Description
TTP 22 is an inhibitor of casein kinase 2 (CK2) that may alter cell survival, cell cycle control, DNA repair, and Wnt signaling; it is likely in development for potential anticancer activity.
TTP 22 is an inhibitor of casein kinase 2 (CK2) that may alter cell survival, cell cycle control, DNA repair, and Wnt signaling; it is likely in development for potential anticancer activity.
Cas No. | 329907-28-0 |
---|---|
Purity | ≥98% |
Formula | C16H14N2O2S2 |
Formula Wt. | 330.42 |
IUPAC Name | 3-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl}propanoic acid |
Solubility | ethanol 20mM DMSO 100mM |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Golub AG, Bdzhola VG, Briukhovetska NV, et al. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem. 2011 Mar;46(3):870-6. PMID: 21276643.
Gao Y, Wang HY. Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling. J Biol Chem. 2006 Jul 7;281(27):18394-400. PMID: 16672224.
Macrolide; vacuolar H+-ATPase inhibitor.
β-lactam cephalosporin; penicillin binding pro...
Flavanol originally found in Camilla (green tea...
inhibits inflammatory signaling
Synthetic compound related to sulforaphane.
Flavonol found in Tagetes.
ITC, erysolin analog.
Antimicrobial peptide found in amphibians.
Peptide toxin found in Conus snails; nAChR inhi...
Benzoylurea, insect growth regulator; chitin sy...
Endogenous opioid peptide; δOR and μOR agonis...
DHF reductase inhibitor.
FGFR inhibitor.
Nitroimidazole, binds DNA; nucleic acid synthes...
Dipeptide ester, commercial sweetener.
Aldose reductase inhibitor.
Indole alkaloid found in Evodia rutaecarpa; top...
c-Raf, RET, VEGFR1 inhibitor, potential HMT inh...
ITC precursor found in cruciferous vegetables.<...
p38 MAPK inhibitor.